独活寄生汤治疗膝骨关节炎机制研究及临床应用-环球中医药杂志.pdfVIP

环球中医药2015年9月第8卷第9期摇 Global Traditional Chinese Medicine,September2015,Vol郾8,No郾9 摇1149 ·综述 · 独活寄生汤治疗膝骨关节炎机制研究及临 床应用 吕顺摇 周军杰摇 谢晓涛摇 高文武摇 陈贤奇摇 刘铖禕 揖摘要铱摇 独活寄生汤是中医学中治疗风寒湿痹,肝肾两虚,气血不足证的经典方剂之一,随着 现代药理研究的不断深入该方已广泛应用于膝骨关节炎治疗。 为进一步探讨独活寄生汤治疗膝骨 关节炎机制,对近五年来其治疗膝骨关节炎基础文献检索分析,发现其可能通过调控炎性细胞因 子、促进软骨细胞增殖、抑制软骨细胞凋亡等方面起到积极作用,从而延缓关节软骨退变,减轻疼 痛,改善关节功能等。 揖关键词铱摇 膝骨关节炎;摇 独活寄生汤;摇 综述 揖中图分类号铱摇 R684.3摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2015郾09郾034 The clinical use and its mechanisms research on angelicae pubescentis and loranthi decoction in KOA treatment摇 LV Shun,ZHOU Jun鄄jie,XIE Xiao鄄tao et al. 摇 Department of Orthopaedics,Putuo Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai200062,China Corresponding author:ZHOUJun鄄jie,E鄄mail:boysroger@126.com 揖Abstract铱摇 Angelicae pubescentis and loranthidecoctionisoneof themost classicalprescriptionin TCM(Traditional Chinese Medicine TCM). It can expel wind鄄damp,relieve pain,benefit to liver and kidney,and tonify Qi鄄blood effectively. As the development of pharmacology of TCM,this decoction is widely used in the treatment of KOA. In order to further investigate the mechanisms of angelicae pubescentis and loranthi decoction in KOA, we summarized the basic researches on the decoction in treating KOA in recent fiveyears. Wefoundthat it may play an important role in regulating inflammatory, stimulating cartilage proliferation,and inhibiting cartilage apoptosis,thus it can delay articular cartilage degeneration,relieve pain,and improvejoint function and so on. 揖Key words铱摇 Knee Osteoarthritis;摇 Angelicae pubescentis and loranthi decoction;摇 Review 摇 摇 独活寄生汤首载于唐代医药学家孙思邈所著 苓、肉桂心、防风、川芎、当归、干地黄、杜仲、人参、 《备急千金要方》,原文记载:“夫腰背痛者,皆由肾 芍药、甘草15 味中药组成,是治疗肝肾两亏,气血 气虚弱,卧冷湿地当风得之,不时速治,喜流入脚 不足之风寒湿痹证的常用方。 膝骨关节炎(knee 膝为偏枯冷痹缓弱疼重,或腰痛挛脚重痹,宜急服