奥沙利铂联合卡培他滨治疗进展期胃癌的临床疗效评估.pdfVIP

安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2017 Jul,21(7) • 1295 • 奥沙利铂联合卡培他滨治疗进展期胃癌的临床疗效评估 何广思，蒋宗惠 (滁州市第一 人 民 医院肿瘤内科，安 徽 滁 州 239000) 摘要：目 的 评估进展期胃癌病人采用奥沙利钼联合卡培他滨治疗的疗效及安全性 。方 法 纳人治疗的进展期胃癌病人共 63例，其中男性28例，女性35例，分为对照组30例,观察组33例;对照组围手术期采用替吉奥联合奥沙利钼方案治疗，观察 组围手术期采用奥沙利钼联合卡培他滨方案治疗；比较两组病人的临床疗效、不良反应与生活质量改善程度 。结 果 对照组 总体有效率36. 7% ,观察组总体有效率为57. 6% ,观察组高于对照组;观察组口腔黏膜炎症总发生率15. 2 % ，对照组口腔黏膜 炎症总发生率46.7% ,观察组显著低于对照组（P 0. 05);其余各项不良反应指标观察组与对照组差异无统计学意义。观察 组生活质量改善率87.9% ,对照组生活质量改善率73. 3% ,观察组高于对照组。结 论 奥 沙利钼联合卡培他滨对进展期胃癌 的治疗作用值得肯定，治疗过程中不良反应发生率较低，有助于改善病人预后。 关键词：胃肿瘤;奥沙利钼;卡培他滨;化学疗法 doi ：10. 3969/j . issn. 1009 - 6469. 2017.07.035 Assessment of the clinical effect of oxaliplatin in combination with capecitabine regimen in the treatment of advanced gastric cancer HE Guangsi , JIANG Zonghui ( Department of Oncology ,Chuzhou First Peoples Hospital ,Chuzhou, Anhui 239000 , China ) Abstract Objective ： To assess the efficacy and safety of oxaliplatin combined with capecitabine in treating patients with advanced gastric cancer. Methods Sixty-three patients with advanced gastric cancer were enrolled, of which 28 males and 35 females were in­ cluded. All the patients were assigned into a control group of 30 cases and an observation group of 33 cases. The control group was peri­ operatively treated with Gio and oxaliplatin regimen, while the observation group was perioperatively treated with oxaliplatin plus capecitabine regimen. Comparison was made between two groups of patients in clinical efficiency, adverse reaction and improvement in the quality of life. Results The total effective rates of the control group and the observation group were 36.1% and 57. 6% respectiv