肝豆状核变性患者血浆同型半胱氨酸与脂蛋白a叶酸等的相关性研究.pdfVIP

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肝豆状核变性患者血浆同型半胱氨酸与脂蛋白a叶酸等的相关性研究.pdf

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()2014 10 8 20 Chin J Clinicians(Electronic Edition),October 15,2014,Vol.8,No.20 3593 a HLDaB12 63 HLD 33 HLD 30 HLD DMPS HcyaB12 DMPS 24 h 35 Hcy P 0.016 7Hcy P 0.05 aP 0.05 B12 P 0.05 P 0.05Hcy B12Hcy aHcy HLD Hcy HLD a aB12 Hcy HLD  Correlation between plasma homocysteine and lipoprotein(a), folate etc. in patients with * hepatolenticular degeneration Wang Yijie , Hu Wenbin, Yu Xiaoling, Wu Junxia, Han Yongzhu, Hu * Jiyuan, Wang Xun, Li Kai, Wang Gongqiang, Yang Renmin. Anhui University of Traditional Chinese Medicine, Hefei 230038, China Corresponding author: Hu Wenbin, Email: hwbzhx@163.com Abstract Objective To explore the correlation between plasma homocysteine and lipoprotein (a), folate, Vitamin B12 in hepatolenticular degeneration(HLD) and the relationship with decoppering therapy. Methods 63 inpatients of HLD were divided into 33 cases of standardized treatment group(specification group) and 30 cases of non-standardized treatment group(non-specification group). The serum concentration of homocysteine(Hcy), lipoprotein (a), folate and vitamin B12 were measured before decoppering therapy with sodium dimercaptosulphonate(DMPS), 24-hour urine copper were remained before drug treatment and after first period treatment with DMPS. 35 cases of normal served as controls(control group). Results The abnormal rate of serum Hcy in non-specification group was higher than that in specification group and control group(P0.05), but there was no statistical significance between specification group and control group(P0.05). The conce