环状rna研究进展及其在hbv相关肝病中的作用-中国肝脏病杂志.pdfVIP

6 ·综述· 《中国肝脏病杂志（电子版）》2016年第8卷第4期 环状RNA研究进展及其在HBV 相关肝病中的作用 1 1 2 1. 330006 2. 颜兴艳 , 向天新, 张守华 （ 南昌大学第一附属医院 感染科，南昌 ； 江西省儿童医院 普外 科，南昌 330006 ） RNA circRNAs RNA non-coding RNA ncRNA RNA 摘要：环状 （ ）是内源性非编码 （ ， ）和竞争性内源 competing endogenous RNA ceRNA circRNAs mRNA （ ， ）家族的新兴成员。 通过特殊的前体 可变剪 3’ 5’ 接，以外显子或内含子环化的形式将 端和 端通过共价键连接起来，形成一个闭合环状结构。目前 研究表明circRNAs广泛存在于生物体中，可通过与miRNA和蛋白质等其他分子相互作用调控基因的 表达并参与疾病的发生和发展，其有望在疾病的预防、诊断及治疗中发挥重要的作用。本文就目前 circRNAs研究进展及其在HBV相关肝病中的作用进行综述。 关键词：环状RNA ；微小RNA ；竞争内源性RNA ；肝炎病毒，乙型 Research progress of circular RNA and its role in HBV-related liver diseases 1 1 2 YAN Xing-yan , XIANG Tian-xing , ZHANG Shou-hua 1.Department of Infectious Diseases, the First （ Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2.Department of Forensic Sursery, Children’s Hospital of Jiangxi Province, Nanchang 330006, China） Abstract : Circular RNA (circ RNAs) is a novel type of non-coding RNA (ncRNA) and competing endogenous RNA (ceRNA), who forms covalently closed loop structure by jointing 3’ and 5’ ends together via exon circularization and intron circularization. Current studies have discovered that circRNAs are widely expressed in eukaryocyte and act as regulator of gene expression by interacting with miRNA, proteins and other molecules. Emerging evidence indicates that circRNA plays the essential role in the development of some diseases and may serve as diagnostic or predictive biomarkers. Herein, we reviewed the current available outcomes and progre