聚γ-谷氨酸-接枝-聚乳酸立体复合纳米胶束制备及性能the.pdfVIP

聚(γ-谷氨酸)-接枝-聚乳酸立体复合纳米胶束制备及性能 1 1,2 2 1 1 戴姝琳 ，刘美庆 ，殷以华 ，蒋 庆 ，张 超 （1. 中山大学工学院，广东广州 510275；2. 武汉理工大学化学与生命科学学院， 广东广州 430070 ） 摘要：胶束的形成是一个动态过程，故胶束的稳定性较差。纳米胶束的稳定性是其作为药物载体的一大软肋。左 旋聚乳酸PLLA 和右旋聚乳酸PDLA 等量混合产生立体复合作用，这种立体复合可应用于胶束的构建，以降低胶 束的 CMC ，提高胶束的稳定性。本文利用聚(- 谷氨酸)- 接枝- 聚左旋乳酸/ 聚(- 谷氨酸)- 接枝- 聚右旋乳酸 (-PGA-g-PLLA/-PGA-g-PDLA)之间的立体复合作用，构建负载抗癌药物的立体复合胶束。这种胶束CMC 值较非 立体复合更低、稳定性更好、载药量大、包封率高、药物释放更缓慢。 关键词：纳米胶束；药物载体；聚乳酸；聚(γ-谷氨酸) ；立体复合 The Preparation and Characterization of Stereocomplex Nanomicelle Based on Poly(Γ-Glutamic Acid) -Graft-Poly(Lactic Acid) 1 1,2 2 1 1 DAI Shulin , LIU Meiqing , YIN Yihua , JIANG Qing , ZHANG Chao (1.School of Engineering, Sun Yat-sen University, Guangzhou, 510275, China；2.School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.) Abstract: Micellization is a dynamic process, and micelles are usually thermodynamically unstable. Poor stability of polymeric micelles as drug carriers has hindered their widely application. Stereocomplexation between equal molar of PLLA and PDLA could be harnessed to construct polymeric micelle with enhanced stability. In this paper, we prepared a stereocomplexed micelle from poly(γ-glutamic acid)-graft-poly(L-lactic acid) (γ-PGA-g-PLLA) and poly(γ-glutamic acid)-graft- poly(L-lactic acid) (γ-PGA-g-PDLA). This stereocomplexed micelle exhibited a lower CMC than its non-stereocomplexed counterparts. Furthermore, higher drug loading content, drug loading efficiency, and slower in vitro dr