端粒结合蛋白TRF2的研究进展-生命科学.PDFVIP

18 3 Vol. 18, No. 3 2006 6 Chinese Bulletin of Life Sciences Jun., 2006 1004-0374(2006)03-0239-05 TRF2 1 201203 2 100049 DNA TRF2 (TTAGGG repeat binding factor-2)Myb TTAGGG TRF1 TIN2 Rap1 TINT1 POT1 Shelterin TRF2 DNA TRF2 TR F2 D N A Q 51 3 A Telomere binding protein TRF2 1,2 1 1 ZHANG Yong-Wei , MIAO Ze-Hong , DING Jian * (1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China; 2 Graduate School of CAS, Beijing 100049, China) Abstract: TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TIN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protect- ing 3 G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells. Key words: TRF2; telomere; DNA damage response system (telomere) ( s h e l t e r i n ) DNA- TRF1TRF2POT1 TIN2TINT1 Rap1 TTAGGG TTAGGG [1] 5 3 T- 3 D- D N A R A D 5 0 DNA- NBS1 MRE11Ku86DNAPKcs 2005-11-25 2006-01-09 30500618) ( 1 9