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多囊卵巢综合征polycysticovarysyndrome-中国试验动物学报
研究报告
补肾促排卵汤对多囊卵巢综合征模型大鼠卵巢形态及性激素的影响??
郭银华1谈勇邹2,奕洁1
?南京中医药大学附属医院生殖医学科
[摘要] 目的 通过观察补肾促排卵汤对多囊卵巢综合征模型大鼠的性激素、抗苗勒氏管激素(anti-Müllerian hormone, 抗苗勒氏管激素R-33【文献标识码】A【文章编号】1671-7856(2016)12-0000-00
Doi:10.3969/j.issn.1671-7856.2016.12.000
Effect of Bushencupailuan Decoction on ovarian morphology and sex hormone levels in rats with polycystic ovary syndrome
GUO Yin-hua1, TAN Yong Zou2, YI-jie1
(1. The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210029 2. Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023)
[abstract] Objective To explore the effect of Bushencupailuan decoction, a Chinese medicine prescription, on polycystic ovary syndrome (PCOS) and its mechanism through observing the sex hormones, anti-Müllerian hormone (AMH) and the morphology of ovaries of PCOS model rats. Methods Bushencupailuan decoction was administered in DHEA-induced PCOS model rats. The pathology of ovaries was examined, and the serum sex hormones and AMH were detected. Results Compared with the normal group, the ovaries of model group rats had severe diffuse cystic dilatation and cystic cavities of different sizes. The granular layer cells were compressed into flat or cubical shapes. Corpora lutea and follicles in various stages of development were rare. Bushencupailuan decoction obviously improved the numbers of mature follicles and corpora lutea, levels of sex hormones and AMH of PCOS model rats compared with those of model rats (P0.05). Conclusions Bushencupailuan decoction can treat PCOS by improving the serum sex hormone levels in PCOS model rats, reduce serum AMH and help restorer ovulation.
[Key words] Polycystic ovary syndrome, PCOS; Rat model; Bushencupailuan decoction; Sex hormones; Anti-Mullerian hormone, AMH; Morphology, ovary
【基金项目】江苏省中医药局2010年度康缘中医药科技创新基金项目(HZ1010KY)。
【作者简介】郭银华(1980-),女,博士生在读,副主任中医师,从事生殖内分泌研究。E-mail:2893332481@。
【通讯作者】谈勇(1956-),女,博士生导师,主任中医师,从事生殖内分泌研究。E-mail:xijun1025@163.com。
多囊卵巢综合征(polycystic ovary syndrome,PCOS
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