p53突变型乳腺癌中Ki67表达水平的临床意义.pdfVIP

3l0 马顺朝 ，等 053突变 型乳腺癌中Ki67表汰水平的临床意义 p53突变型乳腺癌中Ki67表达水平的临床意义 J-3IN,朝 ，焦 昕 ，李 悦。，邹华伟 ClinicalsignificanceofKi67inp53mutation—positivebreastcancer YanShunchao，JiaoXin ，LiYue ，ZouHuawei DepartmentofOtwology，ShengfingHospital ChinaMedicalUniversity，LiaoningShenyang110022，China；DepartmentofRespiratory Medicine，ShenyangChestHospital，LiaoningShenyang110044，China；Department Pathology，ShengfingHospital ChinaMedical Universtiy，LiaoningShenyang 110004，China． 【Abstract】 Objective：Toinvestigatethemutationstatusofp53andtheexpressionofKi67，andexploretheclini— eal significanceoftheircombinedeffectinbreastcancerM ethods：Todetecttheexpressionofp53andKi67 using ilnlnunohistochelnieal SPlnethodin165casesofbreastcancerResults：p53lnutation ratewas55 8％ f92／165) ThepositiveexpressionrateofKi67was691％ (114／165)Thestatusofp53hadnosignificantcorrelationwith age，tmnorsize，lylnphnodeslnetastases，TNM stage，ERandPR expression，buthadapositivecorrelationwithHer一 2expression inthegeneralpopulation，theexpressionofKi67hadnosignificantcorrelationwithtmnorsizeandlylnph nodeslnetastasesSubgroupanalysisshowedthatKi67 hadapositivecorrelationwithtmnorsizeandlylnphnodes taatasesinp53lnutation—positivepatients Condusion：Ki67 hadapositivecorrelationwith tmnorsizeandlylnph nodelnetastasesin p53 lnutation—positive patientsKi67 lnightbeo12ilnportantpredictorofbiologicbehaviorand prognosisinp53lnutation—positivebreastcancerTheprognosticmodelthateonlbinedp53 andKi67 lnightbel~lore valuablelnbreastcancer 【Keywords】breastcancer；p53；Ki67；clinicalsignificance Modern0neology2014，22(02)：0310—0313 【摘要】 目的：探讨乳腺癌组织中p53的突变情况及Ki67的表达水平，明确p53与Ki67联合作用在乳腺癌 临床病理因素上的体现。方法：应用免疫组化 sP法检测165例乳腺癌组织中p53、Ki67的表达，分析其与临 床病理因素之间的关系。结果：p53的突变率为558％(92／165)，Ki67的阳性表达率为 69l％ (114／165)。 p53的突变情况与患者年龄