PTEN、p53和EGFR在乳腺癌中的表达与临床意义.pdfVIP

见代肿瘤医学 2014年 2月 第 22卷第 2朝 MODERNONCOLOGY，Feb2014，VOL22，NO 02 ·345 PTEN、p53和EGFR在乳腺癌中的表达与临床意义 汤永峰 ，谢莉莉 ，冯晓敏 ，李 惠。 ExpressionandclinicalsignificanceofPTEN，p53andEGFRinbreastcarcinoma TangYong~ng ，XieLili，FengXiaomin ，LiHui Department。}Pathology，NalngMedicalUniversity，AffiliatedNa lngMaternityandChildHeathCareHospital，diangsuNalng 210004，China；Na~ongTichenHeathSchool，diangsuNantong226007，China；DepartmentofPathology,，theA,ffEiatedHospitalof Na lngUniversity。}TCM，diangsuNa lng210029，China． 【Abstract】 Objective：ToevaluatethesignfiicanceofPIEN，p53andEGFRintheinvasivebreastcancerandthe relationshipbetweenthesenlarkersandclinlc0pmh0l0 。poral~leteraswellasclinical outcomeM ethods：SP un0一 histochemistt7wasused indetectingtheexpressionofPIEN，p53andEGFR in68casesofbreastcarcinol~laattd 10 casesofbreastfibroadenolna Results：ThepositiveexpressionrateofPIEN，p53andEGFR proteininbreastcarcino— mawere45 6％ ．515％ and58 8％ respectively．whichweresignificantlydifferentthanthatinbreastfibroadenoma (P005)ThexepressionofPIEN，p53andEGFRinbreastcancerwascorrelatedwithhistologicalgrade，lymph nodemetastasisandthestatusofER(P005)ThepositiveexpressionrateofPIENinthedeathgroupwaslower thanthatinthesmvivalgroup，whichhadstatisticallysignificantdifference(P005)；thepositivexepressionrateof p53(P005)attdEGFR(P005)inthedeathgroupissignificantlyhigherthanthatinthesmvival groupCon- du~on：ThedeletionofPIEN as wellasup—regulatedexpressionofp53andEGFR areinvolvedinprogressionand invasionofbreastcarcinol~laattdindicatepoorprognosisThecombineddetectionofthesethreel~larkerscouldindicate earlypathologicaldiagnosisattdprognosisofbreastcarcinol~la 【Keywords】breastcarcinonla；I1『11『1un0hlst0ch sty；PTEN；p53；EGFR ModernOncology2014，22(02)：0345—0349 【摘要】 目的：检测PIEN、p53和EGFR在乳腺癌中的表达，分析它们与乳腺癌临床病理特征的