青光眼A Prospective RandomizedTrial Comparing.pdfVIP

A Prospective Randomized Trial Comparing Intraoperative 5-Fluorouracil Vs Mitomycin C in Primary Trabeculectomy DARRELL WUDUNN, MD, PHD, LOUIS B. CANTOR, MD, ANGELITA M. PALANCA-CAPISTRANO, MD, JONI HOOP, COT, NISHAT P. ALVI, MD, CHARLES FINLEY, MD, VIPUL LAKHANI, MD, ALAN BURNSTEIN, MD, AND STEPHENIE L. KNOTTS ● PURPOSE : To compare the safety and efficacy of intra- topical MMC in reducing IOP of eyes undergoing pri- operative 5-fluorouracil (5-FU) or Intraoperative mito- mary trabeculectomy. (Am J Ophthalmol 2002;134: mycin C (MMC) in eyes undergoing primary tra- 521–528. © 2002 by Elsevier Science Inc. All rights beculectomy. reserved.) ● DESIGN : Prospective double-masked randomized clini- cal trial. NLIKE MOST SURGICAL PROCEDURES, SUCCESS OF ● METHODS : One hundred fifteen eyes of 103 patients glaucoma filtering surgery is achieved through the with uncontrolled intraocular pressure (IOP) despite U 1 inhibition of wound healing. Antimetabolites maximally tolerated medical therapy or laser were pro- such as mitomycin C (MMC) and 5-flurouracil (5-FU) spectively randomized in a double-masked fashion to one have been used in trabeculectomy to delay wound healing of two treatment groups in a single institution setting. and hence to improve the success of surgery. Since the Subject’s eyes underwent primary trabeculectomy with 1980s, these agents have been used as adjuncts to obt