聚合物药物结合物胶束在抗肿瘤药物递送方面的研究进展-药学学报.pdfVIP

7 10 药学学报 Acta Pharmaceutica Sinica 20 16, 51 (5): 7 10 716 合物药物结合物胶束在抗肿瘤药物递送方面的研究进展 尹晓兰, 张 波, 刘永军, 张 娜* ( 山东大学药学院, 山东 济南 2500 12) 摘要: 聚合物药物结合物胶束 (polymer-drug conju gated micelles, PDCM) 作为抗肿瘤药物递送载体具有多 种优势, 可以增加疏水性药物的溶解度, 延长体内循环时间, 提高药物的稳定性, 减小全身毒性, 增强药物的治 疗效果等。而且, 也可以用含有多种功能基团的聚合物来制备多功能聚合物药物结合物胶束。本文介绍了聚合 物药物结合物胶束的概况及各种多功能修饰的聚合物药物结合物胶束, 综述了聚合物药物结合物胶束在抗肿瘤 药物递送方面的研究进 。 关键词: 聚合物药物结合物; 胶束; 肿瘤治疗; 药物递送 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 16) 05-0710-07 Advances in polymer-drug conjugated micelles in the delivery of anticancer drugs * YIN Xiao-lan, ZHANG Bo, LIU Yong-j un, ZHANG Na (School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China ) Abstract : Polymer-drug conjugated micelles have many advantages as delivery vehicles of anticancer drugs. They can increase the solubility of hydrophobic drugs, extend the circulation time in vivo, improve the stability of anticancer drugs, reduce systemic toxicity and enhance the therapeutic effect of anticancer drugs, etc. moreover, a variety of polymers containing functional groups can also be used to prepare multi-functional polymer-drug conju gated micelles. In this article, polymer-drug conju gated micelles are reviewed and various multi-functional modification of polymer-drug conj ugated micelles are introduced, and the recent progress of polymer-drug conju gated micelles in the delivery of anticancer drugs is summarized. Key words: polymer-dr