年产140吨酮基布洛芬成品过程工艺设计2.pdfVIP

目 录 1 产品概述 ···········································1 1.1基本性质············································1 1.2药物相互作用········································ 1 2 工艺描述 ···········································2 2.1反应原理············································2 2.2工艺描述············································2 3 物料衡算 ···········································3 3.1设计参数············································3 3.2计算流程············································3 3.3相关计算············································4 4 能量衡算 ··········································· 4.1热量平衡············································ 4.2相关计算············································ 5 设备选型 ··········································· 5.1设备选取············································ 5.2管 计算············································ 6 污染处理 ··········································· 6.1三废处理············································ 6.2应急处理············································ 7 岗位选派 ·········································· 参考文献 ············································ 附录：1.工艺流程图 2.工艺配管图 3.设备平面布置图 第一章 产品概述 1.1 基本性质 酮基布诺芬的名称（英）：Ketoprofen 、商品名：欧露维、别名：苯酮苯丙酸；酮基布洛芬；优洛芬。 酮基布洛芬：白色结晶性粉末，无臭或几乎无臭。在甲醇中极易溶，在乙醇、 丙酮或乙醚中易溶，在水中几乎不溶。熔点约93—— 96℃。为芳基烷酸类化合物。具有镇痛、消炎及解热作用。消炎作用较布洛芬为 强，副作用小，毒性低，口服易自胃肠道吸收。1次给药后，约0.5～ 2小时可达血浆峰浓度，t1/2为1.6～1.9小时。在血中与血浆蛋白结合力极强。在2 4小时内自尿中的排出率为30%—— 90%，主要以葡萄糖醛酸结合物形式排出。用于类风湿性关节炎、风湿性关节炎、 骨关节炎、关节强硬性脊椎炎及痛风等。 1.2 药物相互作用 饮酒和与其他非甾体类抗炎药同时使用，会增加肠胃道副作用，也有引起 溃疡的危险性。 与阿司匹林 其他水杨酸类药物同用时，不能增加疗效，而胃肠道副作 用及出血 向发生率增高。 与抗凝血药同用，增加出血危险。 本品可增强抗糖尿病药物作用；降低抗高血压药物的降压作用；与皮质激 素类同用，可明显地减缓炎症症状。 不宜与甲氨蝶呤同用，以防中毒。 与丙磺舒和维拉帕米、硝苯地平同用时，要注意降低剂量；与地高辛同用 时，注意调整地高辛用量。 第二章