基于PEG的纳米胶束.pptVIP

PEG-based amphiphilic copolymer and its drug delivery applications PEG: high water solubility ; significant chain mobility; low toxicity; widely applied in biomedical field. various amphiphilic copolymer can be obtained based on PEG, which further self-assemble into micelles in aqueous media. Journal of Controlled Release , 2001, 70(1-2):63–70 diblock copolymer hyperbranched copolymer Biomacromolecules, 2008, 9(10): 2578–2585 Macromolecules, 1995, 28(5): 1698-1703. Boltorn 型 HBPester H40理想结构 hyperbranched-linear-hyperbranched copolymer International Journal of Polymeric Materials, 2012, 61(5): 384-394. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2010, 358(1-3): 128-134. star copolymer Generation 2 PAMAM dendrimer Bioconjugate Chem, 2005, 16(2): 397-405. dendrimer-star copolymer Advanced Drug Delivery Reviews ,2001,47(1):113–131 Annual Review of Biomedical Engineering,2006,8(1):323-341 amphiphilic diblock copolymer Molecules with f 50% can be expected to form micelles, whereas molecules with f25% can be expected to form inverted microstructures. Conventional micelles composed of amphiphilic linear copolymers have suffered from low drug-loading efficacies, insufficient stabilities and rapid initial release rates. Polym Chem, 2015, 6(4): 531-542. PEG-PCL2 miktoarm star copolymers Any number of various types of polymer arms emanate from a core. The observed morphologies of amphiphilic self- assemblies depend on a variety of physicochemical factors, such as temperature, polymer–solvent interactions, and the presence of additives, as well as the preparation methods or micelle forming processes. Polymer, 2017, 110: 235-241. Multi-responsive core-crosslinked micelles The crosslinking structure can improve the drug loading capacity due to the compact and stable structure in aqueous media.