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Name of journal: World Journal of Gastroenterology ESPS Manuscript NO: 15620 Columns: ORIGINAL ARTICLE Basic Study Liuweiwuling tablet attenuates acetaminophen-induced acute liver injury and promotes liver regeneration in mice Lei YC et al. Liuweiwuling tablet attenuates acute liver injury Yan-Chang Lei, Wen Li, Pan Luo Yan-Chang Lei, Department of Infectious Diseases, Zhejiang Hospital, Hangzhou 310013, Zhejiang Province, China Wen Li, Pan Luo, Infectious Diseases Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China Author contributions: Lei YC designed this research; Lei YC, Li W and Luo P performed this research and analyzed the data; Lei YC wrote the paper. Ethics approval: The study was reviewed and approved by the Zhejiang Hospital Institutional Review Board. Conflict-of-interest: The authors declare there are no conflicts of interest to disclose. Data sharing: No additional data are available. Open-Access: This article is an open-access?article?which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed?in?accordance?with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: /licenses/by-nc/4.0/ Correspondence to: Yan-chang Lei, Chief Physician, Department of Infectious Diseases, Zhejiang Hospital, No. 12 Lingyin Road, Hangzhou 310013, Zhejiang Province, China. ycleihust@ Telephone: +86-571 Fax: +86-571Received: November 30, 2014 Peer-review started: November 30, 2014 First decision: January 8, 2015 Revised: February 4, 2015 Accepted: March 30, 2015 Article in press: Published online: Abstract AIM: To explore the mechanism of Liuweiwuling tablet protect acetaminophen-induced acute liver injury. METHODS: Acetaminophen (250mg/kg)