靛红类化合物的抗疟疾活性-国外医药抗生素分册.pdfVIP

国外医药抗生素分册 2017年9月第38卷第5期 . S41 . 靛红类化合物的抗疟疾活性 1 2 3 4 4,* 冯连胜 ，王世浩，宋旭峰 ，徐志 ，强敏 (1 淮北矿业集团袁店一井煤矿，淮北235000 ； 2 湖北工程学院，孝感432000; 3 北京工业大学，北京100124 ； 4 武汉科技大学化学与工程技术学院，武汉430081) 摘要：疟疾是全球性传染病，每年约有5亿人罹患疟疾，死亡近百万。尽管临床上使用的抗疟药物对药敏型疟疾疗效显 著，但是耐药疟原虫的出现使得这类药物的疗效逐年下降。因此，有必要研发新型抗疟药。靛红具有多种生物活性，广泛存在 于药物分子中。近年来的研究表明，靛红类化合物具有潜在的抗疟疾活性，引起了药物化学家的极大兴趣。本文将归纳近年来 靛红类化合物在抗疟疾领域的研究进展，并讨论这类化合物的构-效关系，为更合理的设计抗疟新药提供理论帮助。 关键词：疟疾；疟原虫；靛红；构-效关系 中图分类号：R978.6 文献标识码：A 文章编号：1001-8751(2017)05-0S4 1-07 Isatin Derivatives and Their Antiplasmodial as Well as Antimalarial Activities 1 2 3 4 4 Feng Lian-Sheng , Wang Shi-Hao , Song Xu-Feng , Xu Zhi , Qiang Min (1 Yuandian No.1 Coal Mine of Huaibei Mining (Group) Co. Ltd., Huaibei 235000; 2 School of Chemistry and Materials Science, Hubei Engineering University, Hubei 432000; 3 Beijing University of Technology, Beijing 100124; 4 Wuhan University of Science and Technology, Hubei 430081) Abstract ：Malaria continues its devastating impact on the health of human populations globally, with around 500 million cases and the death of around 1 million individuals annually. The antimalarials currently used in clinical still highly effective against drug-sensitive infections, while the growing spread of resistance requires new and effective antimalarials. Isatins, which displayed diverse biological activities, also showed potential in vitro antiplasmodial and in vivo antimalarial activities, making them promisi