针对骨髓移植病患中铁过载的去铁治疗研究进展-遗传.pdfVIP

Hereditas (Beijing) 2015 年9 月, 37(9): 865 ―872 综 述 针对骨髓移植病患中铁过载的去铁治疗研究进展 1 2 1 李士伟 ，李想 ，关锋 1. 江南大学生物工程学院，无锡 214122; 2. 江南大学无锡医学院，无锡 214122 摘要:骨髓移植是临床上治疗恶性造血系统疾病的常见手段。而铁过载是临床上常见的并发症之一，对病患的 造血功能和治疗后恢复有极大的抑制作用。了解铁过载产生的分子或遗传机制能帮助优化去铁化方案，提高去 铁化治疗的效率。本文总结了骨髓移植前后铁过载现象发生机制的最新研究进展，并阐述了临床上多种去铁治 疗的方案，以期为该类病患铁过载的预防和治疗提供参考。 关键词:骨髓移植；铁过载；去铁治疗 Progress of iron-chelating therapy for iron overload in patients after bone marrow transplantation 1 2 1 Shiwei Li , Xiang Li , Feng Guan 1. School of Biotechnology, Jiangnan University, Wuxi 214122, China； 2. Wuxi Medical School, Jiangnan University, Wuxi 214122, China Abstract: Bone marrow transplantation (BMT) is commonly used to treat hematopoietic system malignant diseases. Iron overload, which is one of the most common complications in patients undergoing BMT, has a negative impact on sur- vival after allogeneic transplantation. Better understanding of molecular mechanisms of iron overload can improve the treatment regime and improve the efficiency for iron-chelating therapy. In this review, we summarize the mechanisms of iron overload in various conditions and the progression of iron-chelating strategies in patients undergoing BMT. This review will provide insights into the prevention and treatment of patients with iron overload after BMT. Keywords: bone marrow transplantation; iron overload; iron-chelating therapy 铁作为许多酶和蛋白的辅助因子，在细胞代谢 池水平升高[2] 。过量的自由铁能够通过芬顿反应 及细胞呼吸等过程中发挥着重要作用[1] 。当体内铁 (Fenton reaction)或哈伯魏反应(Haber-Weiss reaction) 贮存超出正常水平时会出现铁过载，通常表现为血 诱发机体产生大量的活性氧(Reactive oxygen species, 清铁蛋白浓度、转铁蛋白饱和度以及胞内的可变铁 ROS) ，使机体处于氧化应激状态，进而氧化细胞膜 收稿日期: 2015−05−06; 修回日期: 2015−07−22 基金项目: 国家自然科学基金