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pH-Responsive Poly(Ethylene Glycol) block-Polylactide Micelles for Tumor-Targeted Drug Delivery IF:5.2459 ABSTRACT 1 A biodegradable micellar drug delivery system with a p H-responsive sheddable PEG shell was developed using an acetal-linked poly(ethylene glycol)-block-polylactide (PEG-a-PLA) copolymer and applied to the tumoral release ofpaclitaxel (PTX). The micelles with a diameter of ∼100 nm were stable in PBS at pH 7.4, started shedding the shell and aggregating slowly at pH 6.5, and decomposed faster at pH 5.5. PTX-loaded micelles (M-PTX) with a drug loading of 6.9 wt % exhibited pH-trig