【精选】kinetics of hepatitis b surface替诺福韦的表面抗原病毒动力学研究.pdfVIP

Research Article Kinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate 1,⇑ 2 3 4 5 6 Patrick Marcellin , Maria Buti , Zahari Krastev , Robert A. de Man , Stefan Zeuzem , Lillian Lou , 6 6 6 6 6 Anuj Gaggar , John F. Flaherty , Benedetta Massetto , Lanjia Lin , Phillip Dinh , 6 6 7 8 G. Mani Subramanian , John G. McHutchison , Robert Flisiak , Selim Gurel , Geoffrey M. Dusheiko9, E. Jenny Heathcote10 1Service d’Hépatologie and Inserm U773/CRB3, Hôpital Beaujon, University of Paris, Clichy, France; 2Servicio de Medicina Interna Hepatologia, Hospital General Universitari Vall d’Hebron and Ciberehd, Barcelona, Spain; 3 University Hospital St. Ivan Rilsky, Sofia, Bulgaria; 4Erasmus MC University Medical Center, Rotterdam, The Netherlands; 5Medizinische Klinik I, Frankfurt, Germany; 6Gilead Sciences, Foster City, CA, USA; 7Medical University of Bialystok, Bialystok, Poland; 8Uludag Universitesi Tip Fakultesi, Bursa, Gorukle, Turkey; 9Royal Free Hospital, London, UK; 10Toronto Western Hospital, University of Toronto, Toronto, Canada Background Aims: In a study of 266 chronic hepatitis B e anti- Conclusions: HBsAg loss in HBeAg-positive patients receiving gen (HBeAg)-positive patients, 23 experienced hepatitis B sur