济宁医学院论文封面.docVIP

济 宁 医 学 院 成人教育本科学员毕业论文（设计） 题目： 作者： 学院 专业 年级 完成日期： 年 月 日 雷贝拉唑钠治疗消化性溃疡的临床观察 摘要：目的：雷贝拉唑钠10mg/d在消化性溃疡治疗中的疗效及安全性，并与奥美拉唑20mg/d进行比较。方法：采用随机开放对照临床研究。将消化性溃疡患者随机分为四组。A组：口服雷贝拉唑钠片每次10mg；B组：口服奥美拉唑胶囊每次20mg，每日1次；C、D组：在A、B两组基础上分别睡前加服雷尼替丁150mg。结果：四组患者平均胃内ph值，平均中位ph值，夜间平均胃内ph值、夜间平均中位ph值及症状积分下降率比较：C组和D组明显优于A组和B组；A组、B组之间，C组、D组之间无差异。整个试验过程中四组不良反应率分别为2.3%、2.6%、3.3%、3.1%，不良反应发生率相似。结论：雷贝拉唑钠10mg能安全、有效地治疗消化性溃疡，其缓解症状、抑制胃酸的疗效与奥美拉唑20mg相当。 关键词：雷贝拉唑钠；消化性溃疡；质子泵抑制剂；H2受体拮抗剂 　　The Clinical Observation of Rabeprazole Sodium in Peptic Ulcer Treatment 　　Abstract： Objective： To evaluate the effect and safety of Rabeprazole Sodium 10mg/d in peptic ulcer treatment comparing with omeprazole 20mg/d. Method： Patients with peptic ulcer were randomly divided into four groups. A group took Rabeprazole Sodium 10mg/d, B group took Omeprazole 20mg/d, C and D groups each took Ranitidine 150mg q.n in the base of A and B. Result： The compare of average gastric ph, average median ph, average gastric ph at night, average median ph at night and decline rate of symptom integral in the four groups: C and D groups were superior to A and B groups, while there were no difference between A and B, or C and D. The side effect rate of the four groups were 2.3%、2.6%、3.3%、3.1%. They were similar. Conclusion： Rabeprazole Sodium 10mg/d in peptic ulcer treatment were effective and safety, and the effects of easing symptoms, antagonizing? gastric acid were similar to Omeprazole 20mg/d. 　　Key words：Rabeprazole Sodium；Peptic ulcer；Proton pump inhibitor；Histamine 2 receptor antagonist 　　雷贝拉唑钠为新型质子泵抑制剂，通过与H+、K+ATP酶部分可逆地结合，起到抑制胃酸分泌作用。我们通过雷贝拉唑钠10mg/d在消化性溃疡治疗中与奥美拉唑20mg/d进行比较，评价其疗效及安全性。 　　1材料和方法 1病例所有纳入研究的病人均需满足下列入选标准：①内镜下诊断为活动性十二指肠溃疡或活动性胃溃疡门诊病人；年龄为18～65岁，性别不限；溃疡直径在0.3～2.0cm之间，溃疡数目不超过2个；病人签署知情同意书。排除标准为：癌性溃疡和未能排除癌变可能的溃疡；复合性溃疡；有明确的降低胃酸的手术史或食管或胃手术史，单