Chemical Contaminants in Food - JIFSAN食品中化学污染物- jifsan.pptVIP

Sources of Uncertainty and Current Practices for Addressing Them: Exposure Perspective Clarence W. Murray, III, Ph.D. Center for Food Safety and Applied Nutrition June 15, 2011 Outline Definition of terms Dietary exposure model Sources of uncertainty in a dietary exposure assessment Chemical concentration and current practices to address uncertainty Food consumption and current practices to address uncertainty Conclusions Uncertainty The imperfect knowledge concerning the present or future state of an organism, system, or (sub)population under consideration. Variability The heterogeneity of values over time, space or different members of a population. Variability implies real difference among members of that population. Dietary Exposure Assessment The qualitative and/or quantitative evaluation of the likely intake of chemicals (including nutrients) via food, beverage, drinking water, and food supplements. Sources of Uncertainty in Dietary Exposure Assessment Chemical concentration data Food consumption data Sources of Uncertainty in Dietary Exposure Assessment Chemical concentration data Food consumption data Sources of Uncertainty in Chemical Concentration Data Sources of uncertainty: Analytical measurements resulting in non-detect values for the chemical concentration in foods. Summary statistics used to describe the chemical concentration in foods. Sources of Uncertainty in Chemical Concentration Data Sources of uncertainty: Analytical measurements resulting in non-detect values for the chemical concentration in foods. Summary statistics used to describe the chemical concentration in foods. Non-Detects in Chemical Concentration Problem: Analytical techniques are unable to measure chemical concentrations below its limit of detection. Non-detect analytical result does not imply that the chemical is not present in the sample. Non-Detects in Chemical Concentration Current practices for addressing the uncertainty from non-detects: