丹参酮A脉冲微丸的制备与体外质量评价.PDF

( ) JOURNAL OF PEK ING UN IVERSITY (HEALTH SCIENCES) Vol. 2 No. 5 O ct. 2010 559 论著 丹参酮A脉冲微丸的制备与体外质量评价 1 2! 1! 梁雪丹 , 郑 颖 , 范田园 ( 1. , 100191; 2. ) [ ] 目的: A 方法: , (H PMC) / HPMC ( LHPC/HPMC) H PMC / ( HPMC/ Su release) , Surelease, A A ; , A结 果: H PMC LH PC/HPM C A , H PMC /Surelease 3~ 5 h, Surelease , , 30% ~ 0% , A 结论: HPMC Surelease, Surelease , 3~ 5 h A , [ ] ; ; [ ] R28 . 1 [ ] A [] 1671167X( 2010) doi: 10. 3969/ .j issn. 1671167X. 2010. 05. 01 Preparation and in vitro evaluation of tanshinone A pulsatile releasepellets 1 2! 1! LIANG Xuedan , ZHENG Y ing , FAN T ianyuan ( 1. Departm ent of Pharm aceutics, PekingUn iversity School of Pharm aceutical Sciences, Beijing 100191, Ch ina; 2. Institu te of Ch ineseM edical Sciences, Un ivers ity ofM acau, M acao SAR) ABSTRACT Objective: To develope pulsatile release pellets using tansh inone as model drug and evaluate their properties in v itro. Methods: The tansh inone pusatile release pelletsw ith rupturable coatingsw ere prepared by fluid bed. Hydroxy propylm ethyl cellu lose(HPMC), low substituted hydroxy propyl cellulose( LHPC) /HPMC, and HPMC /Sureleae w ere used as sw elling agents respectively, and aqueous ethylcellulose d ispersion Surelease as the material of controlled layer. D issolution expermi ents w ere emp loyed to evaluate the effects of different sw elling agents and w eight gain of each coating layer. Crosssectinos of pellets w ith different sw elling agents were observed by scanning electron m icroscope ( SEM ). The release profiles of tanshinone from the coated pelletsw ere fitted into variousm athematic models. Results: Pelletsw ith HPM C or LHPC /HPMC as sw elling agents cou ld not present a significant release lag