马来酸依那普利叶酸片降压及降同型半胱氨酸的-第三军医大学学报.docVIP

马来酸依那普利叶酸片降压及降同型半胱氨酸的临床应用研究 [摘要] 目的:观察马来酸依那普利叶酸片与依那普利片降压及降同型半胱氨酸(Hcy)疗效的差异比较，为治疗H型高血压提供可靠的临床依据。方法：选取原发性高血压患者，于入选时测定血压、血浆同型半胱氨酸水平，按随机、开放、平行对照的方法将其患者分为依那普利片组和马来酸依那普利叶酸片组，治疗8周；于治疗后4周、8周分别复测血压、血浆同型半胱氨酸水平，进行统计学分析，分析2组治疗方法是否存在显著性差异。结果：马来酸依那普利叶酸片能有效地降低血浆同型半胱氨酸水平，作用显著优于依那普利组。依那普利叶酸片各种不良反应发生率与依那普利类似。结论:马来酸依那普利叶酸片控制H型高血压患者在降Hcy及降压方面均具有较好的效果,为治疗H型高血压提供了重要的临床依据。 [关键词] 　H型高血压;同型半胱氨酸(Hcy);马来酸依那普利叶酸片。 Enalapril maleate tablets folic acid homocysteine lowering blood pressure and clinical application 张红雨* 1郑萍2# 谈礼武3 刘陶文4 屈妍5 陈锋 6潘宏彬7 郝开颜8张弘9 （1、2、3、5、6、7、8:广西省壮族自治区南溪山医院心血管内科,4;广西省壮族自治区南溪山医院肿瘤科；9:广西省壮族自治区南溪山医院检验科 桂林:541002） Zhang Hongyu*1 ,Zheng Ping#2,Tan Liwu ,3Liu Taowen 4,Qu Yan5,Chen Feng6,Pan Hongbin7,Hao Kaiyan8,Zhang Hong9（(1、2、3、5、6、7、8：Guangxi zhuang autonomous region of cardiovascular diseases. NaXi hill hospital，4、Guangxi zhuang autonomous region NaXi hill hospital cancer the physician ;9、Guangxi zhuang autonomous region ofHYPERLINK app:ds:clinical laboratoryclinical laboratory，Guilin：541002,China;） Abstract:HYPERLINK app:ds:objectiveObjective To observe the effect of enalapril maleate folic acid tablets and enalapril tablets in reducing blood pressure and lowering homocysteine ( Hcy ) comparison of the outcomes of treatment for hypertension, type H provide a reliable clinical evidence.Methods Selection of essential hypertension patients, measured blood pressure and plasma homocysteine levels when selected，according to a randomized, open, parallel controlled methods the patients were divided into enalapril tablet and enalapril maleate folic acid tablet, treatment for 8 weeks , respectively retest blood pressure,plasma homocysteine levels after 4 weeks and 8 weeks,through statistical analysis if there was significant difference of tow groups；Results enalapril maleate folic acid can effectively reduce plasma homocysteine levels, significantly better than enalapril . Enalapril folic acid tablets a variety of adverse reaction rates and enalapril in similar;Concl