后期促进因子(apc7)在人大肠癌预后表达的研究late promoting factor (apc7) expressed in npc prognosis of colorectal cancer research.pdfVIP
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后期促进因子(apc7)在人大肠癌预后表达的研究late promoting factor (apc7) expressed in npc prognosis of colorectal cancer research
延边大学瞰学滞基灿k学院彤川.沦文
isa
Anaphase-promotingComplex(APC)7
Prognostic
FactorinHumanColorectal
Cancer
Abstract
Objeetive:Theanaphase the
promoting
of
mitotic aswellasothersubstratesinvolvedin
degradation cyclins
sisterchromatidadhesion.Thiswas
study carriedouttoexaminethe
betweentheAPC and
the
relationship expression
all todeterminetheroleoftheAPCinthecolorectal
variables,in
attempt
cancerandtoevaluatethe an
of aberrantAPCfunctionin
possibility
resectedadenocarcinomaofcolorectum.
surgically Methods:
Immunohistochemicalwas forAPCAndKi一67in103
stainingperformed
casesofAdenocarcinomaandl l casesof
mucinousadenocacarinomaof
the method.Results:Incolon
colorectum,using
avidin—biotin—peroxidase
44 reactionsforAPC.
cancer,thecases(67.7%)showed
immunopositive
The
APC in 3were16
posivityhistologicgrades1,2,and cases(36.3%),
15 13 therectal
cases(34%),andcases(29.7%),respectively.Incancer,
the38 reactionsfor
cases(77.6%)showed APC.The
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