常州地区妇女HPV感染状况调查.pdfVIP

1934 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.10 MAY.2011 常州地区妇女HPV 感染状况调查 朱自强 王秋伟 黄瑞萍 虞 斌 孙达成 张 玢 曹 芳△ (南京医科大学附属常州妇幼保健院 江苏常州 213000) 摘要 目的：研究常州地区普通妇女人群中HPV 感染状况，为宫颈癌的预防及治疗提供理论依据。方法：采用PCR 与基因芯片技 744 HPV 744 术，对常州地区参加妇科体检的 名妇女进行 分型检查，并对不同分型感染情况进行统计学分析。结果： 名妇女中共 HPV 157 21.10% HPV 83.64% 16 检出 阳性者 例，感染率为 。在高危型 感染妇女中，共计 的妇女感染了以下六种亚型，依次是 型 46 58 28 33 24 18 18 31 11 52 11 HPV 例， 型 例， 型 例， 型 例， 型 例以及 型 例。结论：鉴于高危型 与宫颈癌发生的密切关系，对普 通妇女人群展开HPV 检测具有预防与治疗意义。 关键词：人乳头瘤病毒(HPV)；基因芯片技术；宫颈癌 R711.32 A 1673-6273 2011 10-1934-03 中图分类号： 文献标识码： 文章编号： （ ） An Survey of Human Papilloma Virus Infection Situation of Women in Changzhou ZHU Zi-qiang, WANG Qiu -wei, HUANG Rui-p ing, YU Bin, SUN Da-cheng, ZHANG Bin, CAO Fang△ (Changzhou Maternal and Child Care Hosp ital Affiliated to Nanj ing Medical Univercity, 2 13003, Changzhou, China) ABSTRACT Obj ective: To investigate HPV (human papilloma virus) of women in Changzhou for providing theoretical basis of prevention and treatment on the cancer of uterine cervix. Methods: A total of 744 women with HPV in Changzhou were examined by PCR and gene chip technique. Results: Of 744 cases, 157 cases (21.10%) were HPV positive. And of the high risk type HPV, HPV-16, 58, 33, 18, 31 and 52 were the highest infection rate subgroups. Conclusion: There was relationship between the high risk type HPV and incidence of cancer of uterine cervix, it was important to detect the HPV infection for prevention and treatment on the cancer of uterine cervix