一氧化氮与心肌细胞凋亡(英文).pdfVIP

33 6 Vol． 33 No． 6 第 卷 第 期 吉 林 医 药 学 院 学 报 2012 12 Journal of Jilin Medical College Dec． 2012 — 405 — 年 月 :1673-2995 (20 12)06-0405-04 · · 文章编号 综 述 一氧化氮与心肌细胞凋亡 Nitric oxide and cardiomyocyte apoptosis 1 ，Arnoud van der Laarse2 ( 1． ， 1320 13 ;2 ． Department of Car- 李 中言 吉林医药学院附属医院心内科 吉林吉林 diology ，Leiden University Medical Center ，Albinusdreef 2 ，2333 ZA Leiden ，the Netherlands) 摘 要:We have reviewed the role of nitric oxide (NO)in the Apoptosis in cardiomyocytes． NO is a highly reactive signaling molecule produced normally in the heart and is an important modulator of myocardial function． The apoptosis process has two main pathways ，the death receptor pathway and the mitochondria-dependent pathway． NO is an impor- tant regulator of apoptosis within the mammalian system ，capable of both inducing and preventing apoptosis ，depending upon the level of NO production and environmental milieu． 关 键 词:Nitric oxide; apoptosis; cardiomyocyte 中图分类号:R54 1 文献标识码:A 1 Introduction 2 The death receptor pathway Since the first description of apoptosis by Kerr and The apoptotic pathway is mediated by extracellular coworkers in 1972 ［1］apoptosis has been studied in many peptide ligands ，such as tumor necrosis factor (TNF )- cell types． Its importance in normal development ，tissue a ［2］，which binds to members of the