近10年人参皂苷对心血管疾病的药理作用研究进展.pdfVIP

·3736 · 中草药 Chinese Traditional and Herbal Drugs 第 47 卷 第 20 期 2016 年 10 月 近 10 年人参皂苷对心血管疾病的药理作用研究进展 1 1 2 1, 3, 4* 王 巍 ，苏光悦 ，胡婉琦 ，赵余庆 1. 沈阳药科大学中药学院，辽宁 沈阳 110016 2. 延边大学药学院，吉林 延吉 133000 3. 沈阳药科大学，基于靶点的药物设计与研究教育部重点实验室，辽宁 沈阳 110016 4. 沈阳药科大学功能食品与葡萄酒学院，辽宁 沈阳 11016 摘 要：人参单体皂苷作为人参的主要活性物质，可有效抑制心肌细胞肥大、改善心肌缺血，保护心肌缺血再灌注、促进血 管再生、抑制心肌细胞凋亡和抗心律失常等。对近 10 年人参皂苷在心血管疾病的药理作用研究进行综述，为以人参皂苷为 基础的心血管疾病保护剂的新药开发及临床用药提供参考。 关键词：人参；人参皂苷；心血管疾病；心肌细胞肥大；心肌缺血；心肌缺血再灌注；血管再生；心肌细胞凋亡；抗心律失常 中图分类号：R285 文献标志码：A 文章编号：0253 - 2670(2016)20 - 3736 - 06 DOI: 10.7501/j.issn.0253-2670.2016.20.029 Research progress in pharmacological effects of ginsenoside on cardiovascular diseases in last decade 1 1 2 1, 3, 4 WANG Wei , SU Guang-yue , HU Wan-qi , ZHAO Yu-qing 1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China 2. School of Pharmaceutical, Yanbian University, Yanji 133000, China 3. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China 4. School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China Abstract: There are abundant active substances in ginsenoside, which have been used effectually in many fields. Ginseng saponins are the effective components in the treatment of cardiovascular diseases. Many kinds of ginseng saponins have a positive therapeutic effect on inhibiting cardiomyocyte hypertrophy, improving myocardial ischemia, protecting the ischemia-reperfusion myocardium, stimulating angiogenesis, and inhibiting myocardial apoptosis and anti-arrhythmia. This article summarized the research progress in the pharmacological effects o