[医学保健]生物学优势（外放疗相比）.pptVIP

生物学优势（外放疗相比） 肿瘤局部治疗的持续时间长 放射治疗的剂量较低 对周围正常组织的损伤小 对肿瘤细胞的杀伤力强 HE staining 适应症 实体瘤（如前列腺癌）的根治性治疗 实体瘤术后残余组织的预防性治疗 转移性肿瘤病灶或术后孤立性肿瘤转移灶而失去手术价值者 无法手术的原发肿瘤的姑息性治疗 禁忌证 放射性治疗不宜(如血液病等)及有麻醉禁忌等 病灶范围广泛 恶液质、全身衰竭 肿瘤部位有活动性出血、坏死或溃疡 严重糖尿病 Pre-implant CT scan (Case Two) Post-implant CT scan Post-implant CT scan Pre-implant CT scan (Case Three)  Post-implant CT scan Pre-implant CT scan (Case Four)  Post-implant CT scan Post-implant CT scan 国内临床尚有许多问题需要解决 临床应用适应症选择标准不一，造成不同医院应用放射性粒子植入治疗技术后疗效评价缺乏标准，尤其在放射性粒子治疗肿瘤的过程中，现在面临的缺乏行业管理标准和操作技术规范 如不同增殖速率的肿瘤如何选择不同放射性核素,以获得最大的杀伤效应 粒子种植治疗仍是局部治疗手段，是外科和外放疗的补充和延伸，单纯放射性粒子植入治疗并不能解决所有肿瘤治疗问题，如何合理、科学地与外科、外放疗和化疗结合，最大限度发挥粒子植入治疗的优势 展 望 由于放射性粒子植入治疗恶性肿瘤创伤小，靶区剂量分布较均匀和对周围正常组织损伤较小等特点，在临床应用展现了广阔的前景 同样放射性粒子植入技术治疗肿瘤需要多学科联合，特别需要准确的治疗计划、娴熟的治疗技术和严谨的术后质量评估 From this table we can see the karnofsky score step up after intervention. Here is the image of one patient. This is pre-implant CT result, the red arrow showed the location of the mass. Now is the post implant image, we can see the decreased size of the mass and seeds were in place. In terms of complications, there is no serious complication encountered. In drug-seeds combined group there is some reversible side effects like leukopenia and renal function impairment. We are extending our experience of iodine 125 into the field of pancreatic cancer after promising results on liver and lung malignancies. Here is some technical tips to share. Fast the patient and inhibit pancreatic secretion. Transgress the stomach is safer than intestine, keep in mind to avoid puncturing colon. Our preliminary results showed drug-seeds combined therapy had better outcome which need to be validated in the future. Time to draw the conclusion, CT-guided brachytherapy using iodine 125 seeds implantation appeared to be safe, effective, less complicated and could produce adequate pain relief for treating unresectable pancreatic cancer. Thanks all of you for kind your attention. Morning, chairman and dear colleagues, I am Dr. Wang from S