药理学留学生试题 山东大学.doc

Pharmacology Exam for Grade 2003(A) Pakistan Students (Exam 1) — Nov 10th,2005 Part Ⅰ Choice Questions （60 points） Type A (only one answer is correct) 1. Which of the following statements is correct? weak bases are absorbed efficiently across the epithelial cells of the stomach coadministration of atropine speeds the absorption of a second drug drugs showing large Vd can be efficiently removed by dialysis of the plasma. stressful emotions can lead to a slowing of drug absorption. if the Vd for a drug is small, most of the drug is in the extraplasmic space. 2. The drugs that can pass across the blood brain barrier are A. small in molecular weight and ionized drugs B. small in molecular weight and nonionized drugs C. large in molecular weight and ionized drugs D. large in molecular weight and nonionized drugs E. all of above are not true 3. Which of the following statements is correct? if 10mg of drug A produces the same response as 100mg of drug B, drug A is more efficacious than drug B. the greater the efficacy, the greater the potency of a drug in selecting a drug, potency is usually more important than efficacy a competitive antagonist increases ED50 variation in response to a drug among different individuals is most likely to occur with a drug showing a large therapeutic index 4. Which of the following is true for a drug whose elimination from plasma shows first-order kinetics? the half-life of the drug is proportional to the drug concentration in plasma the amount eliminated per unit time is constant the rate of elimination is proportional to the plasma concentration elimination involves a rate-limiting enzyme reaction operating at its maximal velocity E. a plot of drug concentration versus time is a straight line 5. Which of the following drugs has the largest therapeutic index ? A. Drug A LD50=150mg, ED50=100mg B. Drug B LD50=100mg, ED50=50mg C. Drug C LD50=250mg, ED50=100mg D. Drug D LD50=300mg, ED50=50mg E. Drug E LD50=300mg, ED50=150mg 6. A