Introduction to CNS pharmacology中枢神经系统药理学概论.ppt

Temporal summation CNS DRUGS CLASSIFICATION Chemical structure Benzodiazepines, Butyrophenones Pharmacological MAO inhibitors, SSRI, Hallucinogens?? Clinical use Antidepressants, Antipsychotic agents, Amphetamines ?? WHO Classification 1. Anxiolytic sedatives (hypnotics, sedatives, minor tranquillizers) “Drugs that cause sleep and reduce anxiety” Examples Barbiturates, benzodiazepines and ethanol WHO Classification 2. Antipsychotic drugs (neuroleptics, major tranquillizers, anti-schizophrenia “Drugs that are effective in relieving symptoms of schizophrenic illness” Examples Phenothiazines and butyrophenones WHO Classification 3. Antidepressant drugs (thymoleptics) “ Drugs that alleviate the symptoms of depressive illness” Examples TCA, MAOI, SSRI WHO Classification 4. Psychomotor stimulants (Psychostimulants) “Drugs that can cause wakefulness and euphoria” Examples Amphetamines, Cocaine, and caffeine WHO Classification 5. Hallucinogenic drugs (psychodysleptics, psychotomimetics) “Drugs that cause disturbance of perception and of behavior in ways that cannot be simply characterized as sedative or stimulant effects” Examples Lysergic acid diethylamide (LSD), mescaline and phencyclidine Others Analgesics (opiate) Katamine (anesthetics) Nootropics drugs (Piracetam) Home message Pharmacology is easy Understanding of CNS physiology and anatomy enhances understanding of drugs action Pharmacology Range and Dale is better for further reading also read your Katzung Neurotransmitters Lecture on 16/08/07 ?! This is just the beginning… * A fundamental structure necessary for synaptic transmission is the synapse. This is the point where a neuron relays its message to an adjacent neuron. In the CNS there are two major types of synapses: electrical and chemical. This chart outlines some of the major differences between the two….. Introduction to CNS pharmacology Dr. MUSTAFA A. ALSHAGGA CUCMS – Faculty of Pharmacy Objectives You shou