奥美拉唑治疗胃食管反流病的临床研究.docVIP

精品论文 参考文献 奥美拉唑治疗胃食管反流病的临床研究 武汉市黄陂区天河街道卫生院 湖北武汉 430300 【摘 要】目的：探讨奥美拉唑治疗胃食管反流病（GERD）的效果及维持用药的方法。方法：70例GERD随机分为两组，奥美拉唑（O）组40例，第1至4周口服奥美拉唑20mg每日1次，第5至12周改为隔日1次，法莫替丁（F）组为30例，治疗用法莫替丁200mg每日2次加西沙必利5mg每日3次口服，维持用药则单用法莫替丁，观察两组治疗前后症状评分及食管24小时pH监测结果。结果：O组治疗阶段各周末症状评分依次下降（plt;0.05），且分别低于F组（plt;0.05），F组用药后第2、第3及第4周末之间的症状评分差异不大（pgt;0.05）。而第4周末和第5周末症状评分差异有显著意义（plt;0.05）。O组第4、第8和第1 2周末症状完全缓解率分别为95%、93%和90%，分别高于F组的83%，50%和37%。第12周末食管24小时PH监测复查结果显示；治后两组食管酸暴露各项指标均有改善，O组的改善比F组更为明显，O组的酸反流总计分95%（38/40）恢复正常（少于14分），高于F组的40%（12／30）。O组食管炎11例于第12周末均痊愈，而F组10例只痊愈5倒。结论：与法莫替丁加西沙比利疗法比较，奥美拉唑治疗GERD具有症状缓解、完全缓解率高等优点，维持用药只需隔日服药1次，效果明显优于常规剂量的法莫替丁疗法。 【关键词】胃食管反流病；药物治疗；奥美拉唑；法莫替丁 Abstract Objective：To investigate the effect of omeprazole in treatment of gastroesophageal reflux disease（GERD）and the method of maintenance treatment.Methods：70 patients with GERD were randomly divided into two groups，omeprazole（o）group of 40 cases，1 to 4 weeks of oral omeprazole 20mg once daily，5 to 12 weeks change for one time every other day famotidine famotidine（f）group（n = 30）. The treatment with famotidine famotidine 200mg daily 2 times with cisapride 5 mg orally 3 times a day and maintain medication alone famotidine famotidine were observed before and after treatment in the two groups of symptoms and esophageal 24 hours pH monitoring results. Results：the symptom scores of the treatment group were decreased（plt;0.05）in O group，and were lower than those in F group（plt;0.05），and the difference was not significant（F）between second，third and 4 weeks after treatment in pgt;0.05 group. While the score of symptoms was significantly different（plt;0.05）at fourth and fifth weekend. Complete remission rates of fourth，eighth and twelfth in O group were 90%，93% and 95%，respectively，higher than those in group F，83%，50% and 37%，respectively. Twelfth esophageal 24 hours PH monitoring showed that the two groups were improved after treatment，the O group was more obvious than the F group，and the total score o