奥曲肽联合奥美拉唑治疗上消化道出血的疗效观察研究.docVIP

精品论文 参考文献 奥曲肽联合奥美拉唑治疗上消化道出血的疗效观察研究 乐山职业技术学院附属医院 四川 乐山 614218 【摘 要】目的：探究奥曲肽联合奥美拉唑治疗上消化道出血的治疗效果。方法：选择我院2014年6月~2016年5月收治的80例上消化道出血患者进行研究，所有患者随机分为治疗组和对照组，每组40例患者。治疗组患者给予奥曲肽联合奥美拉唑治疗，对照组患者给予单一奥美拉唑治疗，比较两组患者的止血时间和止血效果。结果：两组患者治疗结束后止血效果比较，治疗组总有效率为95.0%，对照组总有效率为72.5%，两组比较差异具有统计学意义（P＜0.05）；两组患者止血时间比较，治疗组平均止血时间为（20.9plusmn;4.3）h，对照组平均止血时间为（29.6plusmn;3.8）h，两组比较差异显著（P＜0.05），具有统计学意义。结论：奥曲肽联合奥美拉唑治疗上消化道出血临床治疗效果显著，具有止血时间短、止血效果好的优点，值得临床广泛推广应用。 【关键词】奥曲肽；奥美拉唑；上消化道出血 [Abstract] Objective：Therapeutic effect of digestive tract hemorrhage of octreotide combined with omeprazole in treatment.Methods：Our hospital in June 2014 ~2016 year in May were studied in 80 cases of upper gastrointestinal bleeding，all patients were randomly divided into treatment group and control group，40 patients in each group. The treatment group was treated with octreotide plus omeprazole treatment，the control group were treated with single omeprazole treatment，compared two groups of patients with bleeding time and bleeding effect.Results：Compare the hemostatic effect of two groups of patients after treatment，the total efficiency of treatment group was 95%，control group total effective rate was 72.5%，with significant differences between the two groups（P lt; 0.05）；compared two groups of patients with bleeding time，the treatment group the average hemostatic time was（20.9 + 4.3）h，the control group average hemostasis time is（29.6 + 3.8）h，there was significant difference between two groups（P lt; 0.05），with statistical significance.Conclusion：Octreotide combined with omeprazole in treatment of upper digestive tract hemorrhage clinical treatment effect is significant，the bleeding time is short，the advantages of good hemostatic effect，it is worthy of wider application. [key word] Octreotide；Omeprazole；upper gastrointestinal hemorrhage 上消化道出血是临床常见的消化系统疾病，主要是指屈氏韧带以上的消化道，包括食管、胃、十二指肠、胆管、胰管等病变引起的出血[1]。消化道大量出血是指在数小时内失血量超过1000mL或超过循环血容量的15%[2]。临床表现为呕血、黑便，血容量急剧减少会引起周围循环衰竭，甚至造成休克，严重威胁着患者的生命健康。上消化大出血病死率可高达8%~13.7%[3]