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Irritable Bowel Syndrome
Irritable Bowel Syndrome – Advances in Diagnosis,
Pathophysiology and Treatment
a report by
Lucinda A Harris , MS , MD
Senior Associate Consultant, Mayo Clinic – Scottsdale, AZ
Introduction hormones mediate this bi-directional brain–gut Lucinda A Harris, MS, MD, is
communication, and serotonin (5-hydroxytryptamine – currently Senior Associate
Forty per cent of the diagnoses made by gastro- 5-HT) has been found to be a key mediator of gut Consultant, Division of
Gastroenterology and Hepatology, at
enterologists are functional bowel disorders. These motility, secretion and sensation.The autonomic nervous the Mayo Clinic in Scottsdale. She
disorders therefore represent the most common disorders system, which is comprised of the parasympathetic, was formerly Associate Professor of
seen by physicians in this specialty. Over 20 functional sympathetic and enteric nervous system, largely mediates Clinical Medicine at the Weill
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