三联疗法对甲亢性骨质疏松患者的疗效观察.docVIP

精品论文 参考文献 三联疗法对甲亢性骨质疏松患者的疗效观察 吴兴初（广西医科大学第六附属医院内分泌科 广西玉林 537000) 　　 　　【摘要】目的 观察阿仑膦酸钠片、阿法骨化醇软胶囊和牡蛎碳酸钙片三联疗法对甲亢性骨质疏松患者（22-44岁）骨密度的影响。方法 将90例甲亢性骨质疏松患者（22-44岁）随机分为3组，抗甲亢药物治疗组（B组）30例，抗甲亢药物加阿法骨化醇软胶囊、牡蛎碳酸钙片治疗组（A1组）30例，抗甲亢药物加阿仑膦酸钠片、阿法骨化醇软胶囊、牡蛎碳酸钙片三联治疗组（A2组）30例；疗程12个月后对比骨密度情况。结果 抗甲亢药物加阿仑膦酸钠片、阿法骨化醇软胶囊、牡蛎碳酸钙片三联治疗组（A2组）腰椎、股骨的骨密度均明显升高（P＜0.05），明显高于A1组（P＜0.05），A1组高于B组（P＜0.05）。结论 三联疗法提高甲亢患者的骨密度更明显。 　　【关键词】三联疗法 甲亢 骨质疏松症 骨密度 　　【中图分类号】R581.1 【文献标识码】A 【文章编号】1672-5085（2013）49-0059-02 　　The efficacy of triple therapy on patients with osteoporosis caused by hyperthyroidism 　　WU Xingchu( The department of endocrinology of Sixth affiliated hospital of Guangxi Medical University. YuLin 537000 China.email:344497880@, tel 　　【Abstract】Objective To observe the effect of bone mineral density (BMD) of patients(22-44 years old)with osteoporosis caused by hyperthyroidism on which triple therapy combined with alendronate sodium tablets、alfa-calcidol soft capsules and oyster calcium carbonate. Methods All 90 patients with osteoporosis caused by hyperthyroidism(22-44 years old) were randomly divided into three groups: antithyroid drug therapy as group B，antithyroid drug combined with alfa-calcidol soft capsules and oyster calcium carbonate therapy as group A1 and antithyroid drug combined with alendronate sodium tablets、alfa-calcidol soft capsules and oyster calcium carbonate therapy as group A2，each of them were all 30 patients. To compare the BMD of patients when therapy for 12 months. Results The BMD of lumbar spine and femoral of group A2 which were treated by antithyroid drug combined with alendronate sodium tablets、alfa-calcidol soft capsules and oyster calcium carbonate was significantly increase(plt;0.05)，and apparently higher than group A1 (plt;0.05),and the BMD of the group A1 was higher than the group B too. Conclusion The triple therapy can significantly increase the BMD of patients with hyperthyroidism. 　　【K