两种四联疗法根除Hp感染消化性溃疡的疗效比较.docVIP

精品论文 参考文献 两种四联疗法根除Hp感染消化性溃疡的疗效比较 刘雅静 　　北京市昌平区医院　北京　昌平　１０２２００ 作者简介:刘雅静女,汉族,１９７８年１月出生,硕士,主治医师,毕业月河北医科大学研究生学院,主要研究方向:脂肪肝的发病机制及药物治疗方面. 　　【摘要】　目的　对两种四联疗法治疗幽门螺杆菌感染(Helicobacterpylori,Hp)消化性溃疡的效果进行比较和探讨.方法　６０例幽门螺杆菌相关性消化性溃疡患者分为对照组和观察组,每组３０例.对照组应用雷呗拉唑、枸橼酸铋钾片、阿莫西林与克拉霉素治疗,观察组应用雷呗拉唑、枸橼酸铋钾片、阿莫西林与呋喃唑酮进行治疗.对采用不同四联疗法治疗的患者的临床疗效及幽门螺杆菌根除率进行比较.结果　经治疗６周后,对照组有１２例治愈,１０ 例有效,８例无效,总有效率为７３．３％ ;观察组有１５例治愈,１３有效,２例无效,总有效率为９３．３３％.组间比较差异具有统计学意义(P＜０．０５).对照组HP根除率为８０％,观察组HP根除率为９３．３％,差异具有统计学意义(P＜０．０５).结论　应用雷呗拉唑、枸橼酸铋钾片、阿莫西林与呋喃唑酮四联疗法治疗幽门螺杆菌相关性消化性溃疡,其治疗效果好于雷呗拉唑、枸橼酸铋钾片、阿莫西林与克拉霉素,可提高HP根除率,促进溃疡面愈合,值得临床推广使用. 【关键词】　幽门螺杆菌感染;消化性溃疡;含铋剂四联疗法TwokindsofquadrupletherapytheeradicationofHppositivecomparethecurativeeffectofpepticulcer　Liuyajing(Beijingchangpingdistricthospital１０２２００)【Abstract】ObjectiveTocomparedanddiscussedthetwokindsofquadrupletherapytreatmentofHelicobacterpyloriinfection(Helicobacterpylori,Hp)pepＧticulcereffects.Methods６０patientswithHpcorrelationofpepticulcerweredividedintocontrolgroupandobservationgroup,３０casesineachgroup.TheconＧtrolgroupusedraybaiazole,bismuthpotassiumcitratetablets,amoxicillinandclarithromycintreatment,Observationgroupusedraybaiazole,bismuthpotassiＧumcitratetablets,amoxicillinandfurazolidonetreatment,Toadoptdifferentquadrupletherapytotreatthepatient＇sclinicalcurativeeffectandhelicobacterpylorieradicationratecomparison．ResultAfter６weekstreatment,therewere１２caseswerecured,１０caseseffective,８casesofinvalidincontrolgroup,ThetotaleffecＧtiveratewas７３．３％;therewere１５caseswerecured,１３caseseffective,２casesofinvalidinobservationgroup,Thetotaleffectiveratewas９３．３％.Comparativedifferencesbetweengroupswithstatisticalsignificance(P＜０．０５)．ThecontrolgroupHperadicateratewas８０％,theobservationgroupHPeradicationratewas９３．３％,Statisticallysignificantdifference(P＜０．０５)．ConclusionUsedraybaiazole,bismuthpotassiumcitratetablets,amoxicillinandfurazolidonequadrupletherapyforhelicobacterpyloripepticulcer,Itstreatmenteffectisbetterthanraybaipullazole,bismuthpotassiumcitratetablets,amoxicillinandclarithromycin,Cani