动态监测重症急性胰腺炎患者血清降钙素原的临床意义.docVIP

精品论文 参考文献 动态监测重症急性胰腺炎患者血清降钙素原的临床意义 杨萍1 吴丹2 　　（1湖北省十堰市太和医院皮肤科湖北医药学院附属医院 湖北十堰 442000） 　　(2湖北省十堰市中心血站 湖北十堰 442000） 　　【摘要】目的：探讨血清降钙素原（procalcitonin,PCT）在重症急性胰腺炎（severe acute Pancreatitis，SAP）中的临床意义。方法：对2012年9月到2014年9月之间的52例被确诊的重症急性胰腺炎患者进行回顾性分析，其中存活38例，死亡14例，分别记录重症胰腺炎患者第1、3、7、转出或死亡当天的PCT水平，同时进行相应的急性生理和慢性健康状况评分（acute physiological and chronic health evaluation, APACHE Ⅱ）和床旁急性胰腺炎严重度评分（bed-side index for severity in acute pancreatitis,BISAP），并对患者的预后情况进行分析。结果：1.死亡组患者PCT浓度、PACHEⅡ评分和BISAP评分和存活组患者比较，两组指标的差异具有统计学意义（P＜0.05）； 2.死亡组中第3天、第7天及治疗结束前PCT浓度明显高于生存组，差异具有统计学意义（P＜0.05），并且死亡组PCT水平呈上升趋势，而存活组PCT水平则成下降趋势，同时死亡组APACHE Ⅱ评分和BISAP评分也明显高于存活组患者，差异具有统计学意义（P＜0.05）。结论：重症急性胰腺炎患者PCT水平与疾病的严重程度有明显的相关性，动态检测PCT水平变化趋势有助于预后的判断。 　　【关键词】降钙素原；重症急性胰腺炎；APACHE Ⅱ评分；BISAP评分 　　【中图分类号】R576 【文献标识码】A 【文章编号】1007-8231（2016）06-0070-02 　　Serum procalcitonin Level in patients with severe acute Pancreatitis:Clinical significance of Its Dynamic Monitoring 　　Yang ping1 Wu dan2 　　1The physical examination center, TaiHe Hospital, Shiyan city , HuBei province, 442000,China 　　2 Department of Clinical Laboratory,.the blood center, Shiyan city , HuBei province, 442000,China 　　【Abstract】Objective To study the clinical application value of the serum procalcitonin(PCT) in patients with severe acute Pancreatitis (SAP). Methods Totallay data of patients with AP who were hospitalized from Sep 2012 to Sep 2014 were analyzed, there were 38 patients survival and 14 patients dead. the serum PCT was determined on the 1、3、7days and the end of treatment,and the patients APACHE Ⅱ scores and BISAP scores was compared,the condition of prognoses was observed. Results 1.there was significant different in the PCT levels、APACHE Ⅱ scores and BISAP scores between survival group and the death group(P＜0.05); 2.the serum PCT level of the patients in the dead group was significantly higher than that in the survived group on the 3th and 7 th day and the end of treatment(P＜0.05), the APACHE Ⅱ sco