卵巢癌患者手术治疗前后血清CA50.CA125和HCY检测的临床意义.docVIP

精品论文 参考文献 卵巢癌患者手术治疗前后血清CA50.CA125和HCY检测的临床意义 孙璐 　　（江苏省沭阳县中医院妇产科 223600） 　　【摘要】目的 探讨了卵巢癌患者手术治疗前后血清CA50.cA125和HCY水平的变化及意义。方法　应用放射免疫分析法和免疫化学法对33例卵巢癌患者进行了手术治疗前后血清CA50.cA125和HCY检测，并与35名正常人作比较。结果　卵巢癌患者在手术治疗前血清CA50.cA125和HCY水平均非常显著地高于正常人（Plt;0.01）术后6个月则与正常人比较无显著性差异（Pgt;0.05）血清CA50水平与cA125和HCY水平呈显著正相关（r=0.6014.0.5982.Plt;0.01）。结论　检测卵巢癌患者血清cA50、cA125和HCY水平的变化可有助于对病情的严重程度、病情的发展做出判断。 　　【关键词】卵巢癌 糖类抗元-50 糖类抗元-125 同型半胱氨酸 　　【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2014）04-0061-02 　　 　　Clinical Significance of measurement of Changes of Serum cA50、cA125 and HCY Levels in postoperative patients with ovary cancer. 　　ShuYang Hospital of JiangSu Province of Chinese Troditional Medicine 　　Gynecology and Obstetrics Department SunLu 　　【Abstract】 Objective :To explore the clinical Significance of changes of Seran cA50、cA125 and HCY levels in postoperative with ovary cancer.Methods : Seran cA50、cA125(with RIA).Seran HCY (with immune chemistry method)levels were measclked in 33 patients with ovary cancer and 35 Controls.Result : Before operation, the Seran cA50, cA125 and HCY Levels were significantly higther than those in controls (plt;0.01), after operation for 6 months, the levels were slight difference from those in controls(pgt;0.05). Seran cA50 levels were positively correlated with Seran cA125 and HCY levels (r=0.6014, 0.5982, plt;0.01). Conclusions: changes of helpful to judge the progression and severity in patients with ovary cancer. 　　【Key words】 overy cancer Carbohydrate antigan-50(cA50) Carbohydrate antigan-125(cA125) Homocysteine(HCY) 　　卵巢癌为妇产科较为常见的恶性肿瘤，早期的诊断和治疗有重要的临床价值。本文报告33例卵巢癌患者手术治疗前后血清CA50.cA125和HCY水平的变化，并就临床价值做初步探讨，现将讨论的结果报告如下： 　　1.资料与方法 　　1.1 临床一般资料 　　1.1.1 病人组：33人。年龄42-66岁，平均55.6岁，均为我院妇产科经临床诊断的卵巢癌患者（包括体征、B超和实验室相关的检测指标，最后经手术后病理切片证实） 　　1.1.2 正常人组：35人，年龄40-65岁，平均53.2岁，均为我院体检中心经体检合格的正常妇女，无心、肝、脾、肾等重要脏器疾患，妇检正常，家族中无肿瘤史。 　　1.2 方法 　　1.2.1 血清CA50、cA125检测：放射免疫分析法。试剂盒由北方免疫试剂研究所提供，操作按说明书。 　　1.2.2 血清HCY 检测：免疫化学法，试剂由深圳晶交生物技