卵巢网状、异源性Sertoli-Leydig细胞瘤临床病理分析.docVIP

精品论文 参考文献 卵巢网状、异源性Sertoli-Leydig细胞瘤临床病理分析 （南京解放军八一医院， 江苏南京 210002） ［摘要］目的 探讨卵巢伴有异源性Sertoli-Leydig 细胞瘤的临床病理学特征，提高正确诊断水平，指导治疗。方法 对1例巨大卵巢有异源成份Sertoli-Leydig 细胞瘤进行临床资料、组织病理和免疫表型观察，复习相关文献。结果 患者年龄21岁，左侧卵巢25cmtimes;20cmtimes;18cm，有巨大包块相应症状体征。行左侧卵巢肿瘤剔除术，病理报告为左卵巢Sertoli-Leydig 细胞中分化并伴有异源性（肠上皮和骨组织），免疫组化：Inhibin（＋），VIM（＋）。术后化疗6次。随访2年预后好。结论 网状、异源性卵巢Sertoli-Leydig 细胞瘤诊断主要依据病理形态学特征，免疫组化有一定的辅助作用。该瘤总预后较好，手术是主要治疗方式，有高危因素患者术后辅助化疗。 ［关键词］卵巢肿瘤；Sertoli-Leydig 细胞瘤；免疫组化；诊断，治疗 Clinical pathological Analysis of Sertoli-Leydig Cell Tumor of Ovary Xiao Mei,Li Gei Mei（Department of Pathology， the 81th Hospital of PLA，Nanjing 210002， China） ［Abstract］ Objective To explore the clinical pathological of Sertoli-Leydig cell tumor of ovary. Methods The clinical data，histopathological examination and immunohistochemical examination of Sertoli-Leydig cell tumor of ovary were observed，and the relevant literatures were reviewed. Results The patient was 21 year old. Size of the left ovary was 25cmtimes;20cmtimes;18cm，and there were symptoms and signs corresponding to large masses. on the left ovary was enucleated.According to the pathology report, Sertoli-Leydig cells of the ovary were differentiated,accompanied by heterology(intestinal epithelium and osseous tissue). Immunohistochemical features：Inhibin（＋），VIM（＋）.Postoperative chemotherapy was performs for 6 times. After a 2-year follow-up, there was a good prognosis. Conclusion Sertoli-Leydig cell tumor of ovary is a kind of rare tumor. The diagnosis mostly depends on the clinic symptoms and histological features，the immunohistochemistry can be helpful for the diagnosis. This tumor generally prognosis is good, there are high risk factors in patients with postoperative adjuvant chemotherapy. ［Key word］Ovarian tumor；Sertoli-Leydig cell tumor；Immunohistochemistry.；Diagnosis；Treatment 卵巢Sertoli-Leydig 细胞瘤（sertoli-Leydig cell tumors ,SLCT）是一种来源于性索-间质的肿瘤，临床上多为散在报道，伴有异源成分时，结构复杂，确诊有一定难度。现将我科收治的1例年轻患者的临床病理资料总结分析，并复习相关文献报道如下。 1 病例报告 患者女