厄贝沙坦对高血压脑梗死患者血清内脂素水平的影响.docVIP

精品论文 参考文献 厄贝沙坦对高血压脑梗死患者血清内脂素水平的影响 周为1 陈蕾1 石洁2 　　(1天津市人民医院 300121;2天津市中心妇产科医院 300100) 　　【摘要】目的 观察高血压脑梗死患者血清内脂素水平的变化以及厄贝沙坦治疗对其有无影响。方法 选取78例高血压脑梗死患者和56名正常对照者，测定2组之间血清内脂素水平的差异，并进一步分析其与临床各指标有无关联。78例高血压脑梗死患者再进一步随机分为常规治疗组和厄贝沙坦组，每组39例。常规治疗组给予常规治疗，而厄贝沙坦组在常规治疗的基础上，给予厄贝沙坦 150 mg/d，治疗4周，检测2组治疗前后血清内脂素的变化。结果 高血压脑梗死患者血清内脂素水平相对于对照组明显较高，差异有统计学意义。相关性分析表明，高血压脑梗死患者的血清内脂素与年龄、收缩压、梗死面积以及神经功能缺损评分呈正相关。治疗4周后，厄贝沙坦组的血清内脂素水平较治疗前明显下降，差异有统计学意义；而常规治疗组的血清内脂素水平与治疗前相比，差异无统计学意义。结论 厄贝沙坦能够降低高血压脑梗死患者的血清内脂素水平。 　　【关键词】 厄贝沙坦 高血压 脑梗死 内脂素 　　【中图分类号】R453 【文献标识码】A 【文章编号】1672-5085（2013）37-0022-02 　　The effect of irbesartan on the level of serum visfatin in hypertensive patients with cerebral infarction 　　【Abstract】Objective To determine the levels of serum visfatin in hypertensive patients with cerebral infarction and the effect of irbesartan on the level of serum visfatin. Methods This study consisted of 78 hypertensive patients with cerebral infarction and 52 healthy subjects. The differences in the levels of serum visfatin were determined between the two groups. Then 78 hypertensive patients with cerebral infarction were randomly divided into regular treatment group and irbesartan group (39 patients in each group). Patients in regular treatment group were given regular treatment. In addition, patients in irbesartan group were treated with irbesartan (20 mg/d) for 4 weeks. The levels of serum visfatin of the two groups before and after treatment were examined. Results The serum levels of visfatin were significantly elevated in hypertensive patient with cerebral infarction than normal controls. Pearson analysis indicated that the levels of serum visfatin were positively associated with age, systolic blood pressure, infarction area and neurological functional deficit scales. After treatment for 4 weeks, the levels of serum visfatin were significantly reduced in irbesartan group compared with those before treatment. However, no significant difference