藤黄属植物的化学成分和药理作用研究进展-天津中草药杂志社.PDF

现代药物与临床 Drugs Clinic 第 27 卷 第 3 期 2012 年 5 月 • 297 • 藤黄属植物的化学成分和药理作用研究进展 1, 2 1* 1, 2 张俊艳 ，韩英梅 ，常允平 1. 天津药物研究院 天津市新药设计与发现重点实验室，天津 300193 2. 天津中医药大学，天津 300193 摘 要：藤黄属植物在东南亚地区广泛分布，其中一些植物作为民间药物有着悠久的用药历史。该属植物普遍具有抗肿瘤、 抗炎、抗菌等药理作用，而且已有呫吨酮、双黄酮、苯甲酮、萜类等多种结构类型的化学成分从该属植物中分离得到。概述 了近十年来从藤黄属植物中分离得到的新化合物和首次发现的天然产物及其化学成分的药理活性研究进展，为该属植物的深 入研究提供依据。 关键词：藤黄属；化学成分；抗肿瘤；抗 HIV ；抗炎 中图分类号：R282.71 ；R285.6 文献标志码：A 文章编号：1674 - 5515(2012)03 - 0297 - 07 Advances in studies on chemical constituents of plants in Garcinia L. and their pharmacological activities 1,2 1 1,2 ZHANG Jun-yan , HAN Ying-mei , CHANG Yun-ping 1.Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 2.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: The plants in Garcinia L. are widely distributed in Southeast Asia and some of them have been used as folk medicine for a long time. The plants from this genera often have antitumor, anti-inflammation, and antibacterial pharmacological activities and chemical constituents, such as xanthones, biflavones, benzophenones, and terpenoids have been isolated from this genera. This paper summarizes these new compounds and natural products firstly isolated from the plants in Garcinia L. and the research progress on their pharmacological activities during last decade, so as to provide the basic evidences for further investigation of the plants in Garcinia L. Key words: Garcinia L.; chemical constituents; antitumor; anti-HIV; anti-inflammation 藤黄属植物多为乔木或灌木，全世界约有 450 到的化学成分主要有呫吨酮类、苯甲酮类、黄酮类、 种，主要分布于亚洲热带地区、非洲南部和波利尼 双黄酮类、萜类等。近几年的研究表明藤黄属植物 西亚西部。我国有 20 多种，主产于福建、海南、广