46例中药注射剂致药品不良反应报告.docVIP

46例中药注射剂致药品不良反应报告 林秀云 王凯文 许伟英 上海中医药大学岳阳临床医学院 上海中医药大学附属市中医医院药剂科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的:了解上海中医药大学附属市中医医院 (以下简称“我院”) 肿瘤科中药注射液致药品不良反应 (adverse drug reaction, ADR) 发生情况, 探讨问题与对策, 为中药注射剂的合理应用提供参考。方法:收集2014年1月—2016年6月我院肿瘤科上报的中药注射剂致ADR报告46例, 对患者的性别与年龄、ADR累及器官和 (或) 系统、引发ADR的中药注射剂及ADR的转归等进行分析, 并分析药品说明书中的“不良反应”与临床所发现的ADR的差异。结果:46例ADR报告中, 女性患者均略多于男性;6075岁患者居多。ADR主要累及皮肤及其附件, 其次为消化系统。肿瘤科目前应用的18种中药注射剂的药品说明书中所描述的“不良反应”详略不一;华蟾素注射液引发的ADR病例数最多, 其次为复方苦参注射液、消癌平注射液。所有ADR经停药、治疗及对症处理后均治愈或好转。结论:中药注射剂致ADR不可忽视, 药品说明书有待补充、规范, 应加强药物的规范化管理, 加强用药监测, 促进合理用药。 关键词： 中药注射剂; 药品不良反应; 合理用药; 作者简介：林秀云 硕士研究生。研究方向:中医儿科。E-mail:102244673@ 作者简介：许伟英 主管药师。研究方向:中药临床药学。E-mail:yzishi@126.com 收稿日期：2017-06-23 基金：上海市进一步加快中医药事业发展三年行动计划项目 (No.ZY3-RCPY-3-1039) Reports on 46 Cases of Adverse Drug Reaction Induced by Traditional Chinese Medicine Injection LIN Xiuyun WANG Kaiwen XU Weiying Yueyang Clinical Medical College of Shanghai University of Traditional Chinese Medicine; Dept. of Pharmacy, Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine; Abstract： OBJECTIVE: To investigate the adverse drug reaction ( ADR) induced by traditional Chinese medicine ( TCM) injection in Oncology department from Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine ( hereinafter referred to as“our hospital”) , and to discuss the problems and countermeasures, so as to provide reference for the rational application of TCM injection. METHODS: 46 cases of ADR reports reported from Oncology department of our hospital from Jan. 2014 to Jun. 2016 were collected, statistical analysis was conducted on patients age and gender, ADR involved organs and ( or) systems, ADR-inducing TCM injections and prognosis, and differences of ADR were fund through analyzing “adverse reactions”in dispensatory and the clinic. RESULTS: Of the 46 ADR cases, there were more females than males