网站大量收购独家精品文档,联系QQ:2885784924

对称二氨基的选择性单酰化 Imidazole-Catalyzed Monoacylation of Symmetrical Diamines.pdf

对称二氨基的选择性单酰化 Imidazole-Catalyzed Monoacylation of Symmetrical Diamines.pdf

  1. 1、本文档共4页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
对称二氨基的选择性单酰化 Imidazole-Catalyzed Monoacylation of Symmetrical Diamines

ORGANIC LETTERS Imidazole-Catalyzed Monoacylation of XXXX Vol. xx, No. x Symmetrical Diamines Sanjeev K. Verma, B. N. Acharya, and M. P. Kaushik* Process Technology De Velopment DiVision, Defence R D Establishment, Jhansi Road, Gwalior-474002 (MP) India mpkaushik@ Received April 17, 2010 ABSTRACT An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system. Monoacylated symmetrical diamines are building blocks1 or these conditions is that the monoacylated intermediate is intermediates2 of several well-established drugs such as more soluble in the solvent (aprotic) than the original cardiotonic agent vesnarinone and the antihypertensive agent diamine.4 Plethoras of indirect5,6 and direct4,7 syntheses of prazosin.3 The synthesis of these compounds involves monoacylated symmetric diamines are reported. However, chemoselective acylation on one nitrogen of symmetrical the reported methods either use dry conditions at very low diamines. However, the d

文档评论(0)

ctuorn0371 + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档