子宫肌瘤患者Ki-67、雌激素受体及孕激素受体水平的变化情况的临床研究.docVIP

精品论文 参考文献 子宫肌瘤患者Ki-67、雌激素受体及孕激素受体水平的变化情况的临床研究 张立波 唐春辉 肖东成 钟 琴 李菊香 　　（眉山市第二人民医院妇产科 眉山 620500） 　　【摘 要】目的：研究子宫肌瘤患者Ki-67、雌激素受体及孕激素受体水平的变化情况。方法：选取我院2012年10月~2014年4月接诊的48例子宫肌瘤患者作为研究对象，将48例患者的子宫肌瘤组织作为观察组，瘤旁正常子宫组织作为对照组。调查分析两组子宫组织的Ki-67、雌激素受体及孕激素受体水平。结果：观察组Ki-67阳性率为72.92%，而对照组仅为6.25%，两组差异比较具有统计学意义（Plt;0.05）。观察组雌激素受体及孕激素受体阳性率分别达到了64.58%、85.42%，而对照组则分别为27.08%、66.67%，两组差异比较具有统计学意义（Plt;0.05）。结论：Ki-67、雌激素受体及孕激素受体三项指标与子宫肌瘤的发生有着密切联系，这三项指标的检测对子宫肌瘤患者病情的诊断具有一定的临床意义。 　　【关键词】子宫肌瘤；Ki-67；雌激素受体；孕激素受体 　　【中图分类号】R737.33 【文献标识码】B 【文章编号】1003-5028（2015）5-0103-02 　　The clinical research to the change circumstances of Ki-67, estrogen receptor and progesterone receptor levels of patients with uterine fibroids 　　【Abstract】Objective：To study the change circumstances of Ki-67, estrogen receptor and progesterone receptor levels of patients with uterine fibroids. Methods：48 patients with uterine fibroids in our hospital from October 2012 to April 2014 were studied. The uterine fibroid tissues of 48 patients were regarded as the observation group, and peritumoral normal uterine tissues were as the control group. Analyzed Ki-67, estrogen receptor and progesterone receptor levels of the two group uterine tissue. Results：The Ki-67-positive rate of the observation group was 72.92%, while the control group was only 6.25%, and the difference of the two groups were statistically significant (P lt;0.05). The estrogen receptor and progesterone receptor-positive rate of the observation group reached 64.58% and 85.42%, while the control group were 27.08% and 66.67%, and the difference of the two groups were statistically significant (P lt;0.05). Conclusion：Three indicators of Ki-67, estrogen receptor and progesterone receptor are closely linked to the occurrence of uterine fibroids, and the detection of three indicators has clinical significance to the diagnosis of the disease in patients with uterine fibroids. 　　【Key words】uterine fibroids; Ki-67; estrogen receptor; progesterone receptor 　　子宫肌瘤是女性