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珠母贝糖胺聚糖的结构初探及其生理活性.PDF
25 2 Vol. 25, No . 2
20014 JOURNAL OF FISHERIES OF CHINA Apr. , 2001
: 1000- 0615( 2001) 02- 0166- 05
1 1 1 2 2 2
吴红棉 , 雷晓凌 , 洪鹏志 , 陈 方 , 吴 铁 , 艾春媚
( 1. , 524025, 2. , 52402 )
: PG2- - 2,
6- ( C- 6- S) , C- 6- S: PG2-
- 2 S180 , 61. 96% 46. %
: ; ; ;
: S968. 2; R9 1.74 : A
The preliminary probe of structure and physiological activity
of glycosaminoglycan from Pinctada martensis
1 1 1 2 2 2
WU Hong-mian , LEI Xiao-ling , HONG Peng-zhi , CHEN Fang , WU Tie , AI Chun-mei
(1. Department of Food Science and Technology, Zhanjiang Ocean University, Zhanj iang 524025, China;
2. harmacological Department of Guangdong Medical College, Zhanj iang 52402 , China)
Abstract :Glycosaminoglycan PG2- - 2 from whole viscera of inctada martensis was obtained after extraction
and purification. The fraction showed that its migration rate was relatively near to that of Chondroitin 6- sulphate
( C- 6- S) by acetate film electrophoresis. The infrared spectra ( IR) of it was similar to that of C- 6- S. The
result of antitumor test in vivo demonstrated that PG2- - 2 could obviously enhance the sensitivity of inhibitive
function of clinical antiturmor drugs, the inhibition rates of which to Sarcoma 180 and Ehrlich. s Ascipes
Carcinoma( EAC) were 61. 96% and 46. % respectively. Moreover, PG2- - 2 had certain function of
anticoagulant by the test in vitro.
Key words: inctada martensis; glycosaminoglycan; structure; physiological activity
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