驼乳对慢性肾功能衰竭大鼠的影响-河南农业科学.PDFVIP

376 2010, Vol. 31, No. 17 食品科学 ※营养卫生 1 2 2 2 2 1 , 潘 蕾 ，王 晶 ，王 娟 ，何俊霞 ，李建美 ，吉日木图 * (1. 内蒙古农业大学 乳品生物技术与工程教育部重点实验室，内蒙古 呼和浩特 010018 ； 2. 内蒙古骆驼保护学会，内蒙古 呼和浩特 010018) 目的：探讨驼乳对腺嘌呤所致大鼠慢性肾功能衰竭的作用。方法：采用腺嘌呤复制慢性肾功能衰竭大鼠 模型，以驼乳作为受试物进行灌胃干预。通过检测大鼠体质量、血肌酐(Scr) 、尿素氮(BUN) 、一氧化氮(NO) 、 超氧化物歧化酶(SOD) 、血清总蛋白(TP) 、钙(Ca) 、磷(P) 、24h 尿量、尿蛋白(UP)及肾脏病理组织学变化，分 析驼乳对慢性肾功能衰竭大鼠的影响。结果：驼乳可降低大鼠 Scr 、BUN 水平，减缓 UP ，调节Ca 、P 的含量， 提高 SOD 、TP 水平，具有保护肾功能的作用。结论：驼乳对慢性肾功能衰竭大鼠的病情起到缓解作用。 驼乳；慢性肾功能衰竭；腺嘌呤 Alleviating Effect of Camel Milk on Chronic Renal Failure in Rats 1 2 2 2 2 1, PAN Lei ，WANG Jing ，WANG Juan ，HE Jun-xia ，LI Jian-mei ，JIRIMUTU * (1. Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China ；2. Camel Protection Association of Inner Mongolia, Hohhot 010018, China) Abstract ：Purpose: To figure out whether camel milk has the ability to alleviate adenine-induced chronic renal failure in rats or not. Methods: Rats with adenine-induced chronic renal failure received intragastric administration of camel milk, distilled water or Niaoduqing once a day for 28 consecutive days. As a normal control, normal rats were given distilled water. During this time, the average body weights of all the rats were measured periodically and they were subjected to determination of some blood and urine biochemical parameters, kidney coefficient calculation and renal histopathological observations at the end of administration. Results: Compared with distilled water, camel milk could reduce serum