封堵术对左向右分流先天性心脏病左心重构的影响.docVIP

精品论文 参考文献 封堵术对左向右分流先天性心脏病左心重构的影响 广西钦州市第二人民医院心内科 广西 钦州535000 摘要 目的：探讨左向右分流先天性心脏病封堵后对心脏左心重构的影响 方法：选择2012年1月至2014年9月于我院心内科成功实施封堵治疗的先天性心脏病患儿156例，包括室间隔缺损70例，动脉导管未闭86例，均为左向右分流病例，应用超声心动图测量封堵术前、术后24小时、术后1个月、3个月、6个月、12个月的左心室舒张末内径(LVDd)左心室收缩末内径(LVDs)、左室射血分数(LVEF)，左室短轴缩短率(LVSF)，并进行对比分析 结果：左向右分流先天性心脏病封堵封堵术后3个月LVDs及LVDd开始明显下降，差异有统计学意义（Plt;0.05）；而LVEF及LVSF于术后24小时、1个月、3个月较术前有所下降（Plt;0.05），6个月（P=0.43）、12个月(P=0.65）后无明显差异。结论：封堵术对左向右分流的先天性心脏病治疗安全、有效，可进一步减少左心重构的发生。 关键词 先天性心脏病 左向右分流 封堵术 心室重构 Impact of Transcatheter Closure on Left Ventricular Remodeling in Patients with Congenital Heart Disease of L-R Shunt Li-yuan Chen, Lin Chen, Hua yan, Yong-guang Lu,Liang hua Liu Qinzhou Guangxi No.535000 The Second Affiliated Hospital of Qinzhou City, Cardiology Department Abstract Objective: to explore the influence of transcatheter closure on left ventricular remodeling in patients with congenital heart disease of L-R shunt. Methods: 156 children with congenital heart disease of L-R shunt including 70 cases of ventricular septal defect, and 86 cases of patent ductus arteriosus from January 2012 to September 2014 were involved in this study. All of them have received transcatheter closure procedure successfully. Echocardiography was applied to obtain the data including left ventricular diastolic end diastolic diameter (LVDd), left ventricular systolic diameter(LVDs), left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) before procedure, and 24h, 1 month, 3 months, 6 months, 12 months after procedure. All indicators were compared among the particular timing as above. Results: compared that at baseline, LVDs and LVDd decreased significantly at 3 months after trascatheter closure procedure respectively (Plt;0.05); LVEF and LVFS at 24h, 1-month, and 3-month after procedure decreased significantly compared with that at baseline(Plt;0.05), but similar with that at 6-month (P=0.43)and 12-month(P=0.65) after procedure. Conclusion: Transcatheter closure enables th