小剂量丙戊酸钠防治小儿复杂性热性惊厥的安全性和有效性研究.docVIP

精品论文 参考文献 小剂量丙戊酸钠防治小儿复杂性热性惊厥的安全性和有效性研究 文启芹 刘俊 明怀志 向峰 　　【摘 要】 目的 探讨小剂量丙戊酸钠防治小儿复杂性热性惊厥的安全性和有效性研究。方法 选择我院儿科2012年8月至2015年8月收治的复杂性热性惊厥患儿120例按照随机数字法分为对照组和研究组，每组60例。对照组患儿采取常规治疗，研究组在对照组治疗基础上口服小剂量丙戊酸钠缓释片。两组患儿均进行全面检查，并随访1年。结果 治疗1 h及24 h内，对照组的惊厥控制率与对照组相比有显著性差异（Plt;0.05），而两组的体温恢复率及意识恢复率均没有显著性差异（Pgt;0.05）。服药6个月后，对照组患儿无不良反应发生，研究组患儿出现3例的不良反应，且经过有效干预后均显著减轻或消失。此外，随访1年后，对照组热性惊厥的复发率达到45.0%，继发癫痫的发病率达到20.0%，而对照组热性惊厥的复发率仅为10.0%，且无继发癫痫。两组差异显著（Plt;0.05）。结论小剂量丙戊酸钠能在保障有效性和安全性的前提下，减少不良反应的发生率，值得临床推广。 　　【关键词】 小剂量丙戊酸钠； 小儿复杂性热性惊厥； 安全性； 有效性 　　WEN Qi-qin,LIU Jun，MING Huai-zhi，XIANG Feng (Child medicine,Kanghua Hospital of Dongguan , Dongguan ,China 523080 ) 　　【Abstract】 Objective To evaluate the efficacy and safety of small dose of sodium valproate in treating infantile complicated febrile convulsion. Methods in our hospital from August 2012 to August 2015, 120 cases of complicated febrile convulsion were divided into control group and study group according to the random number method, 60 cases in each group. The control group received routine treatment, research group in the control group based on the treatment of low dose oral sustained-release sodium valproate tablets. The two groups were all examined and followed up for 1 years. Results in the treatment of 1 h and 24 h, the control group had significant difference compared with the control group (Plt;0.05), while there was no significant difference between the two groups in the rate of body temperature recovery and recovery rate (Pgt;0.05). After 6 months of treatment, no adverse reactions occurred in the control group, 3 cases of adverse reactions in the study group were significantly reduced or disappeared after effective intervention. In addition, after 1 years of follow-up, the recurrence rate of the control group was 45%, the incidence rate of epilepsy was 20%, and the recurrence rate of the control group was only 10%, and there was no secondary epilepsy. The difference between the two groups was significant (Plt;0.05).