尿毒症糖尿病与非糖尿病患者主动脉钙化的情况及其危险因素分析.docVIP

精品论文 参考文献 尿毒症糖尿病与非糖尿病患者主动脉钙化的情况及其危险因素分析 于晓霞 常明 刘红 (大连市中心医院 辽宁大连 116033) 【中图分类号】R587.1 【文献标识码】A【文章编号】1672-5085（2013）18-0196-02 【摘要】 目的 观察尿毒症合并糖尿病与不合并糖尿病患者的主动脉钙化情况，探讨主动脉钙化的危险因素。方法 收集62例维持性血液透析治疗患者的临床资料，按患者是否合并糖尿病将其分成2组，通过胸部X线平片进行主动脉钙化的检测，同时检测血钙、血磷及全段甲状旁腺素（iPTH）水平，进行相关统计学分析。结果 62例尿毒症患者中有54例（87.1%）存在主动脉钙化，其中糖尿病组的主动脉钙化率要明显高于非糖尿病组（Plt;0.05）。多元Logistic回归分析结果显示糖尿病、钙磷乘积是维持性血液透析患者血管钙化的相对危险因素。结论 尿毒症患者有较高的主动脉钙化发生率，且合并糖尿病的患者其主动脉钙化的发生率要明显高于不合并糖尿病的患者，糖尿病、钙磷乘积是主动脉钙化的相对危险因素。 【关键词】尿毒症 糖尿病 主动脉钙化 Camparison of vascular calcification in uremic patients with and without diabetes Yu Xiaoxia,Chang Ming,Liu Hong.Department of Nephrology,Central Hospital of Dalian City,Dalian 116033,Chian 【Abstract】 Objective To observe the status of vascular calcification in uremic patients with and without diabetes,and explore the risk factors. Methods The clinical characteristics of 62 uremic patients were collected. Vascular calcification was evaluated by plain radiographic films of chests.The demographic data were collected.The parameters relating to vascular calcification were analyzed. Results Among the 62 cases of uremic patients , vascular calcification was found on radiographic films in 54 cases(87.1%).The prevalence of vascular calcification were higher in the patients with diabetes than those without diabetes（Plt;0.05）, Logistic regression revealed that diabetes and phosphorus product were the independent risk factors for vascular calcification in uremic patients. Conclusions Uremic patients with diabetes have higher prevalence rate of vascular calcification than those without diabetes, diabetes and phosphorus product were the independent risk factors for vascular calcification in uremic patients. 【Key words】Uremia Diabetes Vascular calcification 血管钙化是维持性血液透析患者常见的并发症之一，是终末期肾脏病患者心血管疾病发生及死亡的重要危险因素[1]，但其具体机制尚不清楚。通常认为糖尿病是动脉粥样硬化最常见、最重要的危险因素之一。因此我们观察了维持性血液透析合并糖尿病与不合并糖尿病患者的主动脉钙化发生情况，并探讨主动脉钙化的危险因素。 一、对象与方法 1. 研究对象：选择2011年10月～2013年01月在大连市中心医院住院且行维持性血液透析治疗的尿毒症患者62例。其