帕罗西汀与奥氮平联合治疗难治性抑郁症的临床疗效观察.docVIP

精品论文 参考文献 帕罗西汀与奥氮平联合治疗难治性抑郁症的临床疗效观察 　李欣 张爱娥 （青岛市黄岛区lt;原胶南市gt;六旺中心卫生院 266500） 　　【摘要】 目的 探讨帕罗西汀与奥氮平联合治疗难治性抑郁症的临床疗效。方法 126例难治性抑郁症患者均于2011年10月-2013年10 月来我院就诊，按照随机数字表法将患者分为观察组及对照组各63例，对照组单独给予帕罗西汀治疗，观察组给予帕罗西汀与奥氮平联合治疗，治疗效果采用汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）进行评价，比较两组治疗5周后临床疗效，治疗前后HAMD评分及HAMA评分。结果 观察组治疗5周后总有效率高于对照组，差异有统计学意义（P＜0.05）。两组治疗前HAMD评分、HAMA评分差异无统计学意义（P＞0.05），治疗1周后、3周后、5周后HAMD评分、HAMA评分均低于治疗前，差异有统计学意义（P＜0.05），观察组治疗1周后、3周后、5周后的HAMD评分、HAMA评分均低于对照组，差异有统计学意义（P＜0.05）。结论 帕罗西汀与奥氮平联合治疗难治性抑郁症临床效果显著，可以在临床推广应用。 　　【关键词】难治性抑郁症 帕罗西汀 奥氮平 　　【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2013）35-0029-02 　　Clinical efficacy of paroxetine and olanzapine in the treatment of refractory depression 　　Lixin zhang aie 　　Huangdao District of Qingdao city (Jiaonan city) six Wang Center Hospital，shandongqingdaio266500,china 　　【Abstract】 Objective To investigate the clinical efficacy of paroxetine and olanzapine in the treatment of refractory depression. Methods 126 cases of patients with refractory depression in October 2011, October 2013 to our hospital, according to a random number table, patients were divided into observation group and control group of 63 patients in the control group given paroxetine alone observation group were given paroxetine and olanzapine combination therapy, treatment with the Hamilton anxiety Scale (HAMA) and Hamilton depression Scale (HAMD) to evaluate the clinical efficacy of five weeks after treatment were compared before and after treatment HAMD score and HAMA score.Results The total observation group after treatment 5 weeks higher efficiency, the difference was statistically significant (P lt;0.05). Before treatment HAMD score, HAMA score difference was not statistically significant (Pgt; 0.05), 1 week after treatment, three weeks later, five weeks after the HAMD score, HAMA scores were lower than before treatment, the difference was statistically significant (P lt;0.05) was observed after 1 week of treatment group, three w