帕罗西汀与氯丙咪嗪治疗强迫症的疗效对比分析.docVIP

精品论文 参考文献 帕罗西汀与氯丙咪嗪治疗强迫症的疗效对比分析 杨娟 朱国辉 山东省潍坊市精神卫生中心 【摘 要】目的：对帕罗西汀与氯丙咪嗪治疗强迫症的疗效进行对比分析。方法：选取自2015年2月至2016年2月在我院接受治疗的100例强迫症患者，通过随机抽样的方法分为两组，每组各50例。一组采用帕罗西汀治疗，另一组采用氯丙咪嗪治疗，对两组患者的临床疗效与不良反应进行对比、分析。结果：两组患者接受治疗后，病情均有所好转，两组组间比较无显著差异，不存在统计学意义（P＞0.05）。帕罗西汀治疗组不良反应发生率为12%，而氯丙咪嗪治疗组的不良反应率为28%，两组组间比较差异显著（P＜0.05），存在统计学意义。结论：帕罗西汀与氯丙咪嗪治疗强迫症均能取得理想的临床疗效，但是采用帕罗西汀治疗的不良反应发生率要明显低于采用氯丙咪嗪治疗，且患者耐受性较好，值得在临床中进一步推广应用。 【关键词】帕罗西汀；氯丙咪嗪；强迫症 【 abstract 】 objective：chlorine in paroxetine and imipramine treatment the curative effect of obsessive-compulsive disorder were analyzed. Methods：from February 2015 to February 2015 in our hospital for treatment of 100 patients with obsessive-compulsive disorder，divided into two groups by the method of random sampling，each 50 cases in each group. Treatment with a set of paroxetine，treatment with another group of chlorine imipramine，on two groups of patients with clinical curative effect and adverse reaction of contrast and analysis. Results：two groups of patients after treatment，the illness is better，is no significant difference between the two way，there is no statistical significance（P gt; 0.05）. Paroxetine in treatment group the incidence of adverse reactions was 12%，and the chlorine imipramine treatment group adverse reaction rate was 28%，the comparison between the two way significant difference（P lt; 0.05），there is statistical significance. Conclusion：paroxetine chlorine and imipramine in the treatment of obsessive-compulsive disorder can achieve ideal curative effect，but the incidence of adverse effects of paroxetine treatment significantly lower than using chlorine imipramine treatment，and patient tolerance is better，worthy of further popularization and application in clinical. Key words：paroxetine；Chlorine imipramine；Obsessive compulsive disorder 【中图分类号】TN751.3+5【文献标识码】A【文章编号】2096-0867（2016）-04-011-01 在临床中，强迫症属于较为常见的疾病，通常氯丙咪嗪在临床治疗强迫症时应用较多，但是副作用比较大，帕罗西汀是一种新型强迫症治疗药物，在临床治疗中已经得到了广大患者的认可。本次研究选取我院收治的100例强迫症患者，采用帕罗西汀与氯丙咪嗪治疗，对其临床疗效进行对比分析，现报告如下。 1 资料与方法