康莱特联合同步放化疗治疗中晚期宫颈癌的临床观察.docVIP

精品论文 参考文献 康莱特联合同步放化疗治疗中晚期宫颈癌的临床观察 1.贵州医科大学附属贵州省人民医院 贵州贵阳 550002；2.贵州省人民医院 贵州贵阳 550002 【摘 要】目的：探讨康莱特注射液联合同步放化疗治疗中晚期宫颈癌的近期疗效、毒副反应及耐受性。方法：107例IIb~IVa期宫颈癌初治患者采用随机法分为实验组和对照组，实验组：康莱特注射液200ml 静滴d1-d21+图像引导调强放疗（IGRT）盆腔放疗+单药顺铂30mg/m2每周一次。对照组：IGRT盆腔放疗+单药顺铂30mg/m2每周一次。两组盆腔外照射剂量及后装剂量相同。结果：两组近期有效率：实验组为89%，对照组为73%，两组比较差异有统计学意义（P＜0.05）；白细胞减少、血红蛋白减少及腹痛腹泻的发生率实验组低于对照组，差异有统计学意义（P＜0.05），但在肝功能损害方面，实验组高于对照组差异有统计学意义（P＜0.05），其余毒副反应评价差异无统计学意义（P﹥0.05）。结论：康莱特注射液联合同步放化疗治疗中晚期宫颈癌的近期疗效肯定、毒副反应较轻（肝功能损害除外）、病人耐受性好。 【关键词】康莱特注射液；宫颈癌；同步放化疗；图像引导调强放疗；顺铂 [Abstract] Objective：To investigate Kanglaite injection combined with radiotherapy and the curative effect of chemotherapy in the treatment of advanced cervical cancer，toxicity and patient tolerance.Methods：107 cases at the beginning of the IIb~IVa cervical carcinoma of stage treatment patients were randomly divided into the experimental group and the control group，the experimental group 55 cases，control group（52 cases）.The experimental group adopted：Kanglaite injection 200 ml intravenous drip d1-d21+ image guided intensity-modulated radiotherapy（IGRT）pelvic radiotherapy + single agent cisplatin 30mg / m2 per week at a time.The control group was used for IGRT pelvic radiotherapy plus cisplatin 30mg/m2 once a week.The two groups were the same as the external radiation dose and the Internal irradiation dose of the same.Results：Two groups of recent efficiency：in the experimental group was 89% and 73% in the control group，the difference between the two groups has statistical significance（P lt; 0.05）；leucopenia decrease in hemoglobin and abdominal pain and diarrhea incidence rate of the experimental group was lower than that of the control group，the difference is statistically significant（P lt; 0.05），but in liver function damage，the experimental group higher than that of the control group，the difference was statistically significant（P lt; 0.05），the toxic and side effects to evaluate differences no statistical significance（P gt; 0.05）.Conclusions：Kanglaite